Version 5.4
Homo sapiens Gene: SEMA6D
Summary
InnateDB Gene IDBG-10567.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEMA6D
Gene Name sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000137872
Encoded Proteins
IDBP-10569
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
IDBP-10571
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
IDBP-10573
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
IDBP-10575
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
IDBP-10591
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
IDBP-10597
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
IDBP-598116
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
IDBP-602234
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
IDBP-585404
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
IDBP-584361
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
IDBP-593797
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
IDBP-592743
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
IDBP-586476
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
IDBP-597979
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
IDBP-592936
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
IDBP-590496
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:47184101-47774223
Strand Forward strand
Band q21.1
Transcripts
ENST00000316364 ENSP00000324857
ENST00000354744 ENSP00000346786
ENST00000358066 ENSP00000350770
ENST00000355997 ENSP00000348276
ENST00000389428 ENSP00000374079
ENST00000389425 ENSP00000374076
ENST00000558014 ENSP00000452815
ENST00000559184 ENSP00000453097
ENST00000560636 ENSP00000453420
ENST00000561133 ENSP00000453530
ENST00000536845 ENSP00000446152
ENST00000561106
ENST00000558816 ENSP00000453661
ENST00000559196 ENSP00000453755
ENST00000558431
ENST00000559064 ENSP00000453518
ENST00000560006 ENSP00000453689
ENST00000537942 ENSP00000442040
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0030215 semaphorin receptor binding
Biological Process
GO:0007275 multicellular organismal development
GO:0007411 axon guidance
GO:0014911 positive regulation of smooth muscle cell migration
GO:0014912 negative regulation of smooth muscle cell migration
GO:0021591 ventricular system development
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027200
View Gene Order
ENSBTAG00000016800
Not yet available
Pathways
NETPATH
REACTOME
REACT_19200
Other semaphorin interactions pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt Q8NFY4
TrEMBL H0YL82 H0YMA6 H0YMV0 Q9H9K4 Q9HAH9
UniProt Splice Variant
Entrez Gene 80031
UniGene Hs.511265 Hs.578644 Hs.594980
RefSeq NM_001198999 NM_020858 NM_024966 NM_153616 NM_153617 NM_153618 NM_153619 XM_005254687
HUGO HGNC:16770
OMIM 609295
CCDS CCDS32224 CCDS32225 CCDS32226 CCDS32227 CCDS32228 CCDS32229
HPRD
IMGT
EMBL AB040912 AC009558 AC012050 AC018900 AC023905 AC044787 AC066615 AC084882 AF389426 AF389427 AF389428 AF389429 AF389430 AK021660 AK022747 BC150253
GenPept AAI50254 AAM69449 AAM69450 AAM69451 AAM69452 AAM69453 BAA96003 BAB13869 BAB14221
RNA Seq Atlas 80031

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca