Version 5.4
Homo sapiens Gene: KDM5B
Summary
InnateDB Gene IDBG-105868.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KDM5B
Gene Name lysine (K)-specific demethylase 5B
Synonyms CT31; JARID1B; PLU-1; PLU1; PPP1R98; PUT1; RBBP2H1A
Species Homo sapiens
Ensembl Gene ENSG00000117139
Encoded Proteins
IDBP-105870
lysine (K)-specific demethylase 5B
IDBP-105872
lysine (K)-specific demethylase 5B
IDBP-105874
lysine (K)-specific demethylase 5B
IDBP-808103
lysine (K)-specific demethylase 5B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:202724491-202809470
Strand Reverse strand
Band q32.1
Transcripts
ENST00000367265 ENSP00000356234
ENST00000367264 ENSP00000356233
ENST00000235790 ENSP00000235790
ENST00000456180
ENST00000472822
ENST00000491153
ENST00000498276
ENST00000467487
ENST00000470573
ENST00000602511 ENSP00000473481
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 102 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 102 [view]
Protein-Protein 75 [view]
Protein-DNA 22 [view]
Protein-RNA 1 [view]
DNA-DNA 4 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0032453 histone demethylase activity (H3-K4 specific)
GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)
GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)
Biological Process
GO:0006351 transcription, DNA-templated
GO:0034720 histone H3-K4 demethylation
GO:0034721 histone H3-K4 demethylation, trimethyl-H3-K4-specific
GO:0045892 negative regulation of transcription, DNA-templated
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042207
View Gene Order
ENSBTAG00000006175
Not yet available
Pathways
NETPATH
REACTOME
REACT_228178
HDMs demethylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL R4GN45
UniProt Splice Variant
Entrez Gene 10765
UniGene
RefSeq NM_006618
HUGO HGNC:18039
OMIM 605393
CCDS CCDS30974
HPRD
IMGT
EMBL AC098934 AC104463
GenPept
RNA Seq Atlas 10765

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca