Version 5.4
Homo sapiens Gene: MAPKAPK2
Summary
InnateDB Gene IDBG-106265.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAPKAPK2
Gene Name mitogen-activated protein kinase-activated protein kinase 2
Synonyms MAPKAP-K2; MK-2; MK2
Species Homo sapiens
Ensembl Gene ENSG00000162889
Encoded Proteins
IDBP-106267
mitogen-activated protein kinase-activated protein kinase 2
IDBP-106269
mitogen-activated protein kinase-activated protein kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21969554
MAPKAPK2 phosphorylation is suppressed by lipomannan derived from virulent Mycobacterium tuberculosis (M.tb), resulting in the potent suppression of TNF biosynthesis and allowing M.tb to subvert host immunity and potentially to increase its virulence.
InnateDB Annotation from Orthologs
Summary
PMID 21969554
[Mus musculus] Mapkapk2 phosphorylation is suppressed by lipomannan derived from virulent Mycobacterium tuberculosis (M.tb), resulting in the potent suppression of Tnf biosynthesis and allowing M.tb to subvert host immunity and potentially to increase its virulence. (Demonstrated in human)
Entrez Gene
Summary This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:206684944-206734283
Strand Forward strand
Band q32.1
Transcripts
ENST00000294981 ENSP00000294981
ENST00000367103 ENSP00000356070
ENST00000493447
ENST00000479009
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 61 [view]
Protein-Protein 58 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006468 protein phosphorylation
GO:0006691 leukotriene metabolic process
GO:0006950 response to stress
GO:0006954 inflammatory response
GO:0006974 cellular response to DNA damage stimulus
GO:0007265 Ras protein signal transduction
GO:0009103 lipopolysaccharide biosynthetic process
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0018105 peptidyl-serine phosphorylation
GO:0019369 arachidonic acid metabolic process
GO:0031572 G2 DNA damage checkpoint
GO:0032496 response to lipopolysaccharide
GO:0032675 regulation of interleukin-6 production
GO:0032680 regulation of tumor necrosis factor production
GO:0034097 response to cytokine
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0044281 small molecule metabolic process
GO:0044351 macropinocytosis
GO:0045087 innate immune response (InnateDB)
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048255 mRNA stabilization
GO:0048839 inner ear development
GO:0051403 stress-activated MAPK cascade
GO:0070935 3'-UTR-mediated mRNA stabilization
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000016528
View Gene Order
ENSBTAG00000038107
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
NetPath_12
BCR pathway
NetPath_22
Leptin pathway
REACTOME
REACT_12524
CREB phosphorylation pathway
REACT_21399
activated TAK1 mediates p38 MAPK activation pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_12065
p38MAPK events pathway
REACT_12033
Signalling to RAS pathway
REACT_24915
Butyrate Response Factor 1 (BRF1) destabilizes mRNA pathway
REACT_25064
Tristetraprolin (TTP) destabilizes mRNA pathway
REACT_150420
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_120956
Cellular responses to stress pathway
REACT_11061
Signalling by NGF pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_200780
Regulation of HSF1-mediated heat shock response pathway
REACT_12529
Signaling by VEGF pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_111102
Signal Transduction pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12058
Signalling to ERKs pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_200819
Cellular response to heat stress pathway
REACT_24994
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_12433
Nuclear Events (kinase and transcription factor activation) pathway
REACT_111217
Metabolism pathway
REACT_21328
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_71
Gene Expression pathway
KEGG
hsa04370
VEGF signaling pathway pathway
hsa04010
MAPK signaling pathway pathway
hsa04722
Neurotrophin signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
mapktrkpathway
Trk receptor signaling mediated by the MAPK pathway
il2_1pathway
IL2-mediated signaling events
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
p38_mk2pathway
p38 signaling mediated by MAPKAP kinases
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.643566
RefSeq NM_004759 NM_032960
HUGO
OMIM
CCDS CCDS1466 CCDS31001
HPRD 11882
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca