InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KCNH1

Summary

InnateDB Gene

IDBG-106484.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNH1

Gene Name

potassium voltage-gated channel, subfamily H (eag-related), member 1

Synonyms

EAG; EAG1; h-eag; Kv10.1

Species

Homo sapiens

Ensembl Gene

ENSG00000143473

Encoded Proteins

IDBP-106486

potassium voltage-gated channel, subfamily H (eag-related), member 1

IDBP-106488

potassium voltage-gated channel, subfamily H (eag-related), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:210678315-211134115

Strand

Reverse strand

Band

q32.2

Transcripts

ENST00000271751	ENSP00000271751
ENST00000367007	ENSP00000355974

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000155	phosphorelay sensor kinase activity
GO:0004871	signal transducer activity
GO:0005216	ion channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding

Biological Process

GO:0000160	phosphorelay signal transduction system
GO:0006355	regulation of transcription, DNA-templated
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0007520	myoblast fusion
GO:0023014	signal transduction by phosphorylation
GO:0034765	regulation of ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005637	nuclear inner membrane
GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000058248

View Gene Order

ENSBTAG00000008710

Not yet available

Pathways

NETPATH

REACTOME

REACT_75770

Voltage gated Potassium channels pathway

REACT_13685

Neuronal System pathway

REACT_75908

Potassium Channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.553187

RefSeq

NM_002238 NM_172362

HUGO

OMIM

CCDS

CCDS1496 CCDS31015

HPRD

04492

IMGT

EMBL

GenPept

RNA Seq Atlas