Homo sapiens Gene: TRAF5 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-106494.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | TRAF5 | ||||||||||||||||||||||
Gene Name | TNF receptor-associated factor 5 | ||||||||||||||||||||||
Synonyms | MGC:39780; RNF84 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000082512 | ||||||||||||||||||||||
Encoded Proteins |
TNF receptor-associated factor 5
TNF receptor-associated factor 5
TNF receptor-associated factor 5
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||
Summary |
TRAF5 is a signal transducer for the TNF receptor superfamily that is involved in TNF-induced NF-kappaB activation and protection from cell death.
TRAF5, along with other TRAFs, is recruited to many TNF-receptor (TNF-R) superfamily members and is an important modulator of the proximal signaling events that occur at the time of receptor engagement and activation. TRAF5 has been shown to be a positive regulator of a number of these receptors that are involved in T cell co-stimulation.
TRAF5, a ubiquitin ligase, is a key molecule in the innate response against viral infection where it mediates the activation of IRF3 and NF-kappaB downstream of MAVS through the recruitment of NEMO.
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||
Summary |
[Mus musculus] The binding of MAVS to Traf2, Traf5, and Traf6 is dependent on virus infection and MAVS polymerization. The TRAF proteins promote ubiquitination that recruits IKBKG binding to the MAVS signalling complex
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Entrez Gene | |||||||||||||||||||||||
Summary |
The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 1:211326615-211374946 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | q32.3 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH |
TNFalpha pathway
RANKL pathway
TWEAK pathway
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REACTOME | |||||||||||||||||||||||
KEGG |
Small cell lung cancer pathway
Pathways in cancer pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Hs.523930 Hs.623582 | ||||||||||||||||||||||
RefSeq | NM_001033910 NM_004619 NM_145759 XM_005273249 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS1497 | ||||||||||||||||||||||
HPRD | 03834 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||