InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NEK2

Summary

InnateDB Gene

IDBG-106516.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NEK2

Gene Name

NIMA-related kinase 2

Synonyms

HsPK21; NEK2A; NLK1; PPP1R111; RP67

Species

Homo sapiens

Ensembl Gene

ENSG00000117650

Encoded Proteins

IDBP-106518

NIMA (never in mitosis gene a)-related kinase 2

IDBP-106520

NIMA (never in mitosis gene a)-related kinase 2

IDBP-594627

NIMA (never in mitosis gene a)-related kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:211658657-211675630

Strand

Reverse strand

Band

q32.3

Transcripts

ENST00000366999	ENSP00000355966
ENST00000366998	ENSP00000355965
ENST00000462283
ENST00000489633
ENST00000540251	ENSP00000440237

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	75 [view]
Protein-Protein	71 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019903	protein phosphatase binding
GO:0046872	metal ion binding

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0001824	blastocyst development
GO:0006468	protein phosphorylation
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0007088	regulation of mitosis
GO:0007126	meiotic nuclear division
GO:0043392	negative regulation of DNA binding
GO:0046602	regulation of mitotic centrosome separation
GO:0046777	protein autophosphorylation
GO:0051225	spindle assembly
GO:0051299	centrosome separation
GO:0051988	regulation of attachment of spindle microtubules to kinetochore
GO:0090307	spindle assembly involved in mitosis
GO:1903126	negative regulation of centriole-centriole cohesion

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000794	condensed nuclear chromosome
GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005874	microtubule
GO:0030496	midbody
GO:0043234	protein complex
GO:0045171	intercellular bridge