Homo sapiens Gene: NSL1
Summary
InnateDB Gene IDBG-106575.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NSL1
Gene Name NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)
Synonyms C1orf48; MIS14;
Species Homo sapiens
Ensembl Gene ENSG00000117697
Encoded Proteins
NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)
NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)
NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)
Protein Structure
Entrez Gene
Summary This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3\' UTR region of this gene on chromosome X. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:212726153-212791782
Strand Reverse strand
Band q32.3
Transcripts
ENST00000366978 ENSP00000355945
ENST00000366977 ENSP00000355944
ENST00000366976 ENSP00000355943
ENST00000473995
ENST00000487995
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
Experimentally validated
Total 40 [view]
Protein-Protein 39 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
Cellular Component
GO:0000444 MIS12/MIND type complex
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Separation of Sister Chromatids pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
M Phase pathway
Mitotic Anaphase pathway
Cell Cycle, Mitotic pathway
Resolution of Sister Chromatid Cohesion pathway
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q96IY1
TrEMBL Q53FM2 Q5SY74 Q5SY76
UniProt Splice Variant
Entrez Gene 25936
UniGene
RefSeq NM_001297737 NM_001297739 NM_015471 XM_006711267
HUGO HGNC:24548
OMIM 609174
CCDS CCDS1509 CCDS73025
HPRD 12378
IMGT
EMBL AC104333 AF201941 AF255793 AK222996 AK223260 AL050084 AL591647 BC007067 CH471100
GenPept AAF86877 AAG44640 AAH07067 BAD96716 BAD96980 CAB43260 CAI17046 EAW93379 EAW93380
ImmGen NSL1 (murine)
RNA Seq Atlas 25936