Homo sapiens Gene: NSL1

Summary
InnateDB Gene IDBG-106575.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol NSL1
Gene Name NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)
Synonyms C1orf48; MIS14
Species Homo sapiens
Ensembl Gene ENSG00000117697
Encoded Proteins
IDBP-106577 NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)
IDBP-106579 NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)
IDBP-106581 NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)
IDBP-106583 NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)
IDBP-390009 NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)
Entrez Gene
Summary This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1: 212899495-212965124
Strand Reverse strand
Band q32.3
Transcripts
ENST00000366978  ENSP00000355945
ENST00000366977  ENSP00000355944
ENST00000366976  ENSP00000355943
ENST00000366975  ENSP00000355942
ENST00000422588  ENSP00000388406
ENST00000473995 
ENST00000487995 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
Experimentally validated
Total 41 [view]
Protein‑Protein  40
[view]
Protein‑DNA 1
[view]
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0000087 M phase of mitotic cell cycle
GO:0000236 mitotic prometaphase
GO:0000278 mitotic cell cycle
GO:0007059 chromosome segregation
GO:0051301 cell division
Cellular Component
GO:0000444 MIS12/MIND type complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000062510 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000011340 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_682 Mitotic Prometaphase
REACT_150425 Resolution of Sister Chromatid Cohesion
REACT_150471 Separation of Sister Chromatids
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q96IY1 
TrEMBL E7ETD5 H7BY54 Q53FM2 Q5SY74 Q5SY76
UniProt Splice Variant
Entrez Gene 25936 
UniGene
RefSeq NM_001042549  NM_015471 
HUGO 24548 
OMIM 609174
CCDS CCDS1509  CCDS53474 
HPRD 12378
IMGT
EMBL AC104333 AF201941 AF255793 AK222996 AK223260 AL050084 AL591647 BC007067 CH471100
GenPept AAF86877  AAG44640  AAH07067  BAD96716  BAD96980  CAB43260  CAI17045  CAI17046  CAI17047  EAW93379  EAW93380 
ImmGen NSL1 (murine) 
RNA Seq Atlas 25936