Homo sapiens Gene: NSL1
Summary
InnateDB Gene IDBG-106575.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol NSL1
Gene Name NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)
Synonyms C1orf48; MIS14;
Species Homo sapiens
Ensembl Gene ENSG00000117697
Encoded Proteins
NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)
NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)
NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)
NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)
NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)
Protein Structure
Entrez Gene
Summary This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:212899495-212965124
Strand Reverse strand
Band q32.3
Transcripts
ENST00000366978 ENSP00000355945
ENST00000366977 ENSP00000355944
ENST00000366976 ENSP00000355943
ENST00000366975 ENSP00000355942
ENST00000422588 ENSP00000388406
ENST00000473995
ENST00000487995
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
Experimentally validated
Total 41 [view]
Protein-Protein 40 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000087 M phase of mitotic cell cycle
GO:0000236 mitotic prometaphase
GO:0000278 mitotic cell cycle
GO:0007059 chromosome segregation
GO:0051301 cell division
Cellular Component
GO:0000444 MIS12/MIND type complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Resolution of Sister Chromatid Cohesion pathway
Mitotic Prometaphase pathway
Separation of Sister Chromatids pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q96IY1
TrEMBL E7ETD5 H7BY54 Q53FM2 Q5SY74 Q5SY76
UniProt Splice Variant
Entrez Gene 25936
UniGene
RefSeq NM_001042549 NM_015471
HUGO 24548
OMIM 609174
CCDS CCDS1509 CCDS53474
HPRD 12378
IMGT
EMBL AC104333 AF201941 AF255793 AK222996 AK223260 AL050084 AL591647 BC007067 CH471100
GenPept AAF86877 AAG44640 AAH07067 BAD96716 BAD96980 CAB43260 CAI17045 CAI17046 CAI17047 EAW93379 EAW93380
ImmGen NSL1 (murine)
RNA Seq Atlas 25936