Version 5.4
Homo sapiens Gene: SMYD2
Summary
InnateDB Gene IDBG-106640.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMYD2
Gene Name SET and MYND domain containing 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143499
Encoded Proteins
IDBP-106644
SET and MYND domain containing 2
IDBP-390015
SET and MYND domain containing 2
IDBP-390016
SET and MYND domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).[supplied by OMIM, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:214281102-214337131
Strand Forward strand
Band q32.3
Transcripts
ENST00000366957 ENSP00000355924
ENST00000415093 ENSP00000388682
ENST00000416415 ENSP00000409822
ENST00000491455
ENST00000471645
ENST00000460580
ENST00000484459
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000993 RNA polymerase II core binding
GO:0002039 p53 binding
GO:0005515 protein binding
GO:0016279 protein-lysine N-methyltransferase activity
GO:0046872 metal ion binding
GO:0046975 histone methyltransferase activity (H3-K36 specific)
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0008285 negative regulation of cell proliferation
GO:0010452 histone H3-K36 methylation
GO:0016571 histone methylation
GO:0018026 peptidyl-lysine monomethylation
GO:0018027 peptidyl-lysine dimethylation
GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026603
View Gene Order
ENSBTAG00000013166
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
p53regulationpathway
p53 pathway
Cross-References
SwissProt Q9NRG4
TrEMBL I6L9H7
UniProt Splice Variant
Entrez Gene 56950
UniGene Hs.731769
RefSeq NM_020197
HUGO HGNC:20982
OMIM 610663
CCDS CCDS31022
HPRD
IMGT
EMBL AF226053 AK313868 AL929236 BC017080 BC098133 BC098276 BC098305 BC098335
GenPept AAF86953 AAH17080 AAH98133 AAH98276 AAH98305 AAH98335 BAG36596 CAH70920
RNA Seq Atlas 56950

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca