Version 5.4
Homo sapiens Gene: KCNK2
Summary
InnateDB Gene IDBG-106654.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNK2
Gene Name potassium channel, subfamily K, member 2
Synonyms hTREK-1c; hTREK-1e; K2p2.1; TPKC1; TREK; TREK-1; TREK1
Species Homo sapiens
Ensembl Gene ENSG00000082482
Encoded Proteins
IDBP-246766
potassium channel, subfamily K, member 2
IDBP-246768
potassium channel, subfamily K, member 2
IDBP-390017
potassium channel, subfamily K, member 2
IDBP-390018
potassium channel, subfamily K, member 2
IDBP-481082
potassium channel, subfamily K, member 2
IDBP-484747
potassium channel, subfamily K, member 2
IDBP-477788
potassium channel, subfamily K, member 2
IDBP-479502
potassium channel, subfamily K, member 2
IDBP-484148
potassium channel, subfamily K, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:215005775-215237093
Strand Forward strand
Band q41
Transcripts
ENST00000391895 ENSP00000375765
ENST00000391894 ENSP00000375764
ENST00000444842 ENSP00000394033
ENST00000457122 ENSP00000413460
ENST00000486921 ENSP00000418706
ENST00000467031 ENSP00000420203
ENST00000478774 ENSP00000420569
ENST00000470177 ENSP00000419633
ENST00000474771 ENSP00000420499
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005267 potassium channel activity
GO:0005515 protein binding
GO:0015271 outward rectifier potassium channel activity
GO:0019870 potassium channel inhibitor activity
GO:0022841 potassium ion leak channel activity
Biological Process
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037624
View Gene Order
ENSBTAG00000004407
Not yet available
Pathways
NETPATH
REACTOME
REACT_75819
TWIK related potassium channel (TREK) pathway
REACT_75897
Tandem pore domain potassium channels pathway
REACT_13685
Neuronal System pathway
REACT_75908
Potassium Channels pathway
KEGG
hsa04971
Gastric acid secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.497745
RefSeq NM_001017424 NM_001017425 NM_014217
HUGO
OMIM
CCDS CCDS31024 CCDS41466 CCDS41467
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca