Version 5.4
Homo sapiens Gene: ESRRG
Summary
InnateDB Gene IDBG-106680.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ESRRG
Gene Name estrogen-related receptor gamma
Synonyms ERR3; ERRgamma; NR3B3
Species Homo sapiens
Ensembl Gene ENSG00000196482
Encoded Proteins
IDBP-106682
estrogen-related receptor gamma
IDBP-106684
estrogen-related receptor gamma
IDBP-106686
estrogen-related receptor gamma
IDBP-106688
estrogen-related receptor gamma
IDBP-106690
estrogen-related receptor gamma
IDBP-106692
estrogen-related receptor gamma
IDBP-106694
estrogen-related receptor gamma
IDBP-246774
estrogen-related receptor gamma
IDBP-295739
estrogen-related receptor gamma
IDBP-477677
estrogen-related receptor gamma
IDBP-483590
estrogen-related receptor gamma
IDBP-475707
estrogen-related receptor gamma
IDBP-485150
estrogen-related receptor gamma
IDBP-476619
estrogen-related receptor gamma
IDBP-474610
estrogen-related receptor gamma
IDBP-480653
estrogen-related receptor gamma
IDBP-482815
estrogen-related receptor gamma
IDBP-722204
IDBP-811401
estrogen-related receptor gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]
This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5\' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:216503246-217137755
Strand Reverse strand
Band q41
Transcripts
ENST00000366940 ENSP00000355907
ENST00000361525 ENSP00000355225
ENST00000359162 ENSP00000352077
ENST00000366938 ENSP00000355905
ENST00000361395 ENSP00000354584
ENST00000360012 ENSP00000353108
ENST00000366937 ENSP00000355904
ENST00000391890 ENSP00000375761
ENST00000408911 ENSP00000386171
ENST00000493603 ENSP00000419594
ENST00000463665 ENSP00000418629
ENST00000487276 ENSP00000419155
ENST00000493748 ENSP00000417374
ENST00000475275 ENSP00000419514
ENST00000469486 ENSP00000417900
ENST00000459955 ENSP00000420370
ENST00000481543 ENSP00000418895
ENST00000469913
ENST00000477799
ENST00000471371
ENST00000488947
ENST00000459825
ENST00000586199 ENSP00000466343
ENST00000616180 ENSP00000481528
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0003708 retinoic acid receptor activity
GO:0005496 steroid binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0050682 AF-2 domain binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0010467 gene expression
GO:0043401 steroid hormone mediated signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048384 retinoic acid receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026610
View Gene Order
ENSBTAG00000010392
Not yet available
Pathways
NETPATH
REACTOME
REACT_15525
Nuclear Receptor transcription pathway pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.444225 Hs.605365
RefSeq NM_001134285 NM_001243505 NM_001243506 NM_001243507 NM_001243509 NM_001243510 NM_001243511 NM_001243512 NM_001243513 NM_001243514 NM_001243515 NM_001243518 NM_001243519 NM_001438 NM_206594 NM_206595 XM_006711203 XM_006711204 XM_006711205 XM_006711206 XM_006711207 XM_006711208 XM_006711209
HUGO
OMIM
CCDS CCDS1517 CCDS41468 CCDS58060 CCDS58061
HPRD 04274
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca