Version 5.4
Homo sapiens Gene: RAB3GAP2
Summary
InnateDB Gene IDBG-106744.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAB3GAP2
Gene Name RAB3 GTPase activating protein subunit 2 (non-catalytic)
Synonyms AurAps1; p150; RAB3-GAP150; RAB3GAP150; SPG69; STK6P; WARBM2
Species Homo sapiens
Ensembl Gene ENSG00000118873
Encoded Proteins
IDBP-106746
RAB3 GTPase activating protein subunit 2 (non-catalytic)
IDBP-478201
RAB3 GTPase activating protein subunit 2 (non-catalytic)
IDBP-474257
RAB3 GTPase activating protein subunit 2 (non-catalytic)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the RAB3 protein family, members of which are involved in regulated exocytosis of neurotransmitters and hormones. This protein forms the Rab3 GTPase-activating complex with RAB3GAP1, where it constitutes the regulatory subunit, whereas the latter functions as the catalytic subunit. This gene has the highest level of expression in the brain, consistent with it having a key role in neurodevelopment. Mutations in this gene are associated with Martsolf syndrome.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:220148293-220272454
Strand Reverse strand
Band q41
Transcripts
ENST00000358951 ENSP00000351832
ENST00000237724
ENST00000491005
ENST00000474966
ENST00000491305
ENST00000478976
ENST00000484658 ENSP00000418560
ENST00000474178 ENSP00000420156
ENST00000475769
ENST00000462353
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0030234 enzyme regulator activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006886 intracellular protein transport
GO:0043085 positive regulation of catalytic activity
GO:0043087 regulation of GTPase activity
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039318
View Gene Order
ENSBTAG00000012585
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
botulinumtoxinpathway
Effects of Botulinum toxin
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.601737 Hs.654849 Hs.659103 Hs.708165
RefSeq NM_012414
HUGO
OMIM
CCDS CCDS31028
HPRD 11471
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca