Version 5.4
Homo sapiens Gene: NVL
Summary
InnateDB Gene IDBG-106894.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NVL
Gene Name nuclear VCP-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143748
Encoded Proteins
IDBP-106896
nuclear VCP-like
IDBP-106900
nuclear VCP-like
IDBP-246805
nuclear VCP-like
IDBP-390054
nuclear VCP-like
IDBP-478011
nuclear VCP-like
IDBP-812909
nuclear VCP-like
IDBP-480781
nuclear VCP-like
IDBP-475037
nuclear VCP-like
IDBP-478296
nuclear VCP-like
IDBP-482698
nuclear VCP-like
IDBP-481169
nuclear VCP-like
IDBP-479591
nuclear VCP-like
IDBP-481708
nuclear VCP-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:224227334-224330387
Strand Reverse strand
Band q42.11
Transcripts
ENST00000281701 ENSP00000281701
ENST00000340871 ENSP00000341362
ENST00000391875 ENSP00000375747
ENST00000436927 ENSP00000394884
ENST00000469968 ENSP00000419420
ENST00000481213 ENSP00000479235
ENST00000483094
ENST00000489194
ENST00000493060
ENST00000469075 ENSP00000417826
ENST00000482491 ENSP00000417213
ENST00000496393
ENST00000462893
ENST00000467882 ENSP00000419930
ENST00000492281 ENSP00000418380
ENST00000488718 ENSP00000419828
ENST00000470989 ENSP00000419586
ENST00000470903
ENST00000461466
ENST00000498767
ENST00000461546 ENSP00000418085
ENST00000468673
ENST00000487758
ENST00000468088
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0009378 four-way junction helicase activity
GO:0016301 kinase activity
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026516
View Gene Order
ENSBTAG00000006718
Not yet available
Cross-References
SwissProt O15381
TrEMBL E7EWK7 Q96PA2
UniProt Splice Variant
Entrez Gene 4931
UniGene Hs.497867
RefSeq NM_001243147 NM_001243146 NM_002533 NM_206840 XM_006711772 XM_006711774 XM_006711775 XM_006711776 XM_006711777
HUGO HGNC:8070
OMIM 602426
CCDS CCDS58063 CCDS1541 CCDS1542 CCDS58062
HPRD 03887
IMGT
EMBL AC092809 AF401208 AK297396 AK298244 BC012105 U68140 U78772
GenPept AAB70457 AAB70460 AAH12105 AAL02167 BAG59836 BAG60510
RNA Seq Atlas 4931

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca