Version 5.4
Homo sapiens Gene: TAX1BP1
Summary
InnateDB Gene IDBG-10692.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAX1BP1
Gene Name Tax1 (human T-cell leukemia virus type I) binding protein 1
Synonyms CALCOCO3; T6BP; TXBP151
Species Homo sapiens
Ensembl Gene ENSG00000106052
Encoded Proteins
IDBP-10694
Tax1 (human T-cell leukemia virus type I) binding protein 1
IDBP-237752
Tax1 (human T-cell leukemia virus type I) binding protein 1
IDBP-294614
Tax1 (human T-cell leukemia virus type I) binding protein 1
IDBP-369508
Tax1 (human T-cell leukemia virus type I) binding protein 1
IDBP-369512
Tax1 (human T-cell leukemia virus type I) binding protein 1
IDBP-369593
Tax1 (human T-cell leukemia virus type I) binding protein 1
IDBP-369606
Tax1 (human T-cell leukemia virus type I) binding protein 1
IDBP-369610
Tax1 (human T-cell leukemia virus type I) binding protein 1
IDBP-808352
Tax1 (human T-cell leukemia virus type I) binding protein 1
IDBP-594997
Tax1 (human T-cell leukemia virus type I) binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 17283140
TAX1BP1 is a nuclear receptor co-activator that forms a complex with the glucocorticoid receptor (NR3C1). TAX1BP1 can bind Tax, a human T-cell leukemia virus type 1 oncoprotein, directly and this induces the dissociation of TAX1BP1 from the glucocorticoid receptor-containing protein complex, and represses the co-activator function of TAX1BP1.
PMID 20304918
TAX1BP1 and TNFAIP3 (A20) inhibit antiviral signalling by targeting TBK1/IKKi kinases and disrupting the TRAF3-TBK1-IKKi signalling complex.
PMID 21765415
TAX1BP1 phosphorylation by CHUK is pivotal for the proinflammatory cytokine-dependent assembly of the A20 ubiquitin-editing complex to limit inflammatory gene activation. (Demonstrated in mouse)
InnateDB Annotation from Orthologs
Summary
PMID 21765415
[Mus musculus] Tax1bp1 phosphorylation by Chuk is pivotal for the proinflammatory cytokine-dependent assembly of the A20 ubiquitin-editing complex to limit inflammatory gene activation.
Entrez Gene
Summary This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:27739331-27844564
Strand Forward strand
Band p15.2
Transcripts
ENST00000265393 ENSP00000265393
ENST00000396319 ENSP00000379612
ENST00000409980 ENSP00000386515
ENST00000418691 ENSP00000411490
ENST00000422800 ENSP00000395290
ENST00000433216 ENSP00000391907
ENST00000416801 ENSP00000391215
ENST00000457186 ENSP00000412575
ENST00000490455
ENST00000494033
ENST00000488564 ENSP00000477282
ENST00000460059
ENST00000543117 ENSP00000444811
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 37 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019900 kinase binding
Biological Process
GO:0006915 apoptotic process
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032480 negative regulation of type I interferon production
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004535
View Gene Order
ENSBTAG00000019020
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_25271
Negative regulators of RIG-I/MDA5 signaling pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL C9J7J4 C9JBZ7
UniProt Splice Variant
Entrez Gene 8887
UniGene Hs.34576 Hs.604744 Hs.612386 Hs.707122
RefSeq NM_001079864 NM_001206901 NM_001206902 NM_006024
HUGO HGNC:11575
OMIM 605326
CCDS CCDS43561 CCDS5415 CCDS56471
HPRD 05618
IMGT
EMBL AC004549 AC005091
GenPept
RNA Seq Atlas 8887

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca