Version 5.4
Homo sapiens Gene: POLR3D
Summary
InnateDB Gene IDBG-10695.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLR3D
Gene Name polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
Synonyms BN51T; RPC4; RPC53; TSBN51
Species Homo sapiens
Ensembl Gene ENSG00000168495
Encoded Proteins
IDBP-10697
polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
IDBP-234566
polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
IDBP-480185
polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
IDBP-474749
polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:22245104-22254600
Strand Forward strand
Band p21.3
Transcripts
ENST00000306433 ENSP00000303088
ENST00000397802 ENSP00000380904
ENST00000519237 ENSP00000429677
ENST00000518039 ENSP00000429821
ENST00000517789
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
Experimentally validated
Total 40 [view]
Protein-Protein 40 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003899 DNA-directed RNA polymerase activity
Biological Process
GO:0006383 transcription from RNA polymerase III promoter
GO:0006385 transcription elongation from RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0010467 gene expression
GO:0032481 positive regulation of type I interferon production
GO:0032728 positive regulation of interferon-beta production
GO:0045087 innate immune response
GO:0045089 positive regulation of innate immune response
GO:0051607 defense response to virus
Cellular Component
GO:0000790 nuclear chromatin
GO:0005654 nucleoplasm
GO:0005666 DNA-directed RNA polymerase III complex
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000776
View Gene Order
ENSBTAG00000010036
Not yet available
Pathways
NETPATH
REACTOME
REACT_22339
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_63
RNA Polymerase III Transcription Termination pathway
REACT_756
RNA Polymerase III Chain Elongation pathway
REACT_571
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
REACT_1036
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
REACT_347
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
REACT_281
RNA Polymerase III Transcription Initiation pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_1371
RNA Polymerase III Transcription pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
REACT_71
Gene Expression pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00230
Purine metabolism pathway
hsa03020
RNA polymerase pathway
hsa04623
Cytosolic DNA-sensing pathway pathway
INOH
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.148342 Hs.694963
RefSeq NM_001722
HUGO
OMIM
CCDS CCDS34858
HPRD 01755
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca