Version 5.4
Homo sapiens Gene: LEFTY2
Summary
InnateDB Gene IDBG-106991.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LEFTY2
Gene Name left-right determination factor 2
Synonyms EBAF; LEFTA; LEFTYA; TGFB4
Species Homo sapiens
Ensembl Gene ENSG00000143768
Encoded Proteins
IDBP-106993
left-right determination factor 2
IDBP-390083
left-right determination factor 2
IDBP-807566
left-right determination factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:225936598-225941489
Strand Reverse strand
Band q42.12
Transcripts
ENST00000366820 ENSP00000355785
ENST00000420304 ENSP00000388009
ENST00000474493
ENST00000616737 ENSP00000484300
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005160 transforming growth factor beta receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0002576 platelet degranulation
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007275 multicellular organismal development
GO:0007596 blood coagulation
GO:0016049 cell growth
GO:0030168 platelet activation
GO:0040007 growth
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031093 platelet alpha granule lumen
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_111059
Regulation of signaling by NODAL pathway
REACT_111057
Signaling by NODAL pathway
REACT_111045
Developmental Biology pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_604
Hemostasis pathway
KEGG
hsa04350
TGF-beta signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.520187 Hs.613871
RefSeq NM_001172425 NM_003240
HUGO
OMIM
CCDS CCDS1549 CCDS53479
HPRD 03526
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca