Version 5.4
Homo sapiens Gene: LIN9
Summary
InnateDB Gene IDBG-107021.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIN9
Gene Name lin-9 homolog (C. elegans)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183814
Encoded Proteins
IDBP-107023
lin-9 homolog (C. elegans)
IDBP-107029
lin-9 homolog (C. elegans)
IDBP-107033
lin-9 homolog (C. elegans)
IDBP-481478
lin-9 homolog (C. elegans)
IDBP-477174
lin-9 homolog (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:226231149-226309869
Strand Reverse strand
Band q42.12
Transcripts
ENST00000366808 ENSP00000355773
ENST00000328205 ENSP00000329102
ENST00000359525 ENSP00000352515
ENST00000460719 ENSP00000418121
ENST00000481685 ENSP00000418489
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0006351 transcription, DNA-templated
GO:0007049 cell cycle
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005654 nucleoplasm
GO:0017053 transcriptional repressor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000058729
View Gene Order
ENSBTAG00000033267
Not yet available
Pathways
NETPATH
REACTOME
REACT_111214
G0 and Early G1 pathway
REACT_1006
Polo-like kinase mediated events pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_115566
Cell Cycle pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.120817 Hs.602018 Hs.602486
RefSeq NM_001270409 NM_001270410 NM_173083 XM_005273102 XM_006711767
HUGO
OMIM
CCDS CCDS1553
HPRD 13990
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca