Version 5.4
Homo sapiens Gene: ADCK3
Summary
InnateDB Gene IDBG-107062.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADCK3
Gene Name aarF domain containing kinase 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163050
Encoded Proteins
IDBP-107066
aarF domain containing kinase 3
IDBP-107068
aarF domain containing kinase 3
IDBP-107070
aarF domain containing kinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:226897536-226987545
Strand Forward strand
Band q42.13
Transcripts
ENST00000366779 ENSP00000355741
ENST00000366778 ENSP00000355740
ENST00000366777 ENSP00000355739
ENST00000485677
ENST00000478406
ENST00000489044
ENST00000476488
ENST00000485462
ENST00000479852
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0006744 ubiquinone biosynthetic process
GO:0008219 cell death
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026489
View Gene Order
ENSBTAG00000021880
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.118241
RefSeq NM_020247 XM_005273201 XM_005273202 XM_005273203
HUGO
OMIM
CCDS CCDS1557
HPRD 07375
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca