Version 5.4
Homo sapiens Gene: NKD2
Summary
InnateDB Gene IDBG-10720.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NKD2
Gene Name naked cuticle homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000145506
Encoded Proteins
IDBP-10724
naked cuticle homolog 2 (Drosophila)
IDBP-10726
naked cuticle homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:1008829-1038943
Strand Forward strand
Band p15.33
Transcripts
ENST00000274150 ENSP00000274150
ENST00000296849 ENSP00000296849
ENST00000519933
ENST00000523688
ENST00000513296
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0019838 growth factor binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006887 exocytosis
GO:0010954 positive regulation of protein processing
GO:0016055 Wnt signaling pathway
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0048210 Golgi vesicle fusion to target membrane
GO:0072661 protein targeting to plasma membrane
GO:0090004 positive regulation of establishment of protein localization to plasma membrane
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0016323 basolateral plasma membrane
GO:0016328 lateral plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0071944 cell periphery
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021567
View Gene Order
ENSBTAG00000034435
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04310
Wnt signaling pathway pathway
INOH
PID NCI
wnt_canonical_pathway
Canonical Wnt signaling pathway
Cross-References
SwissProt Q969F2
TrEMBL
UniProt Splice Variant
Entrez Gene 85409
UniGene Hs.240951
RefSeq NM_001271082 NM_033120
HUGO HGNC:17046
OMIM 607852
CCDS CCDS3859 CCDS59486
HPRD
IMGT
EMBL AB062887 AF358137 BC004940 BC012176
GenPept AAH04940 AAH12176 AAK57486 BAB70501
RNA Seq Atlas 85409

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca