Homo sapiens Gene: HIST3H3 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-107261.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | HIST3H3 | ||||||||||||||||||
Gene Name | histone cluster 3, H3 | ||||||||||||||||||
Synonyms | H3.4; H3/g; H3FT; H3t | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000168148 | ||||||||||||||||||
Encoded Proteins |
histone cluster 3, H3
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 1:228424845-228425325 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | q42.13 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 207 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
No orthologs found for this gene | |||||||||||||||||||
Pathways | |||||||||||||||||||
NETPATH |
EGFR1 pathway
TNFalpha pathway
IL4 pathway
FSH pathway
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REACTOME |
Meiotic synapsis pathway
Packaging Of Telomere Ends pathway
Meiotic recombination pathway
Cellular responses to stress pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Condensation of Prophase Chromosomes pathway
Signaling by Wnt pathway
Chromosome Maintenance pathway
Telomere Maintenance pathway
Signal Transduction pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
M Phase pathway
Cellular Senescence pathway
TCF dependent signaling in response to WNT pathway
Mitotic Prophase pathway
Cell Cycle, Mitotic pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
formation of the beta-catenin:TCF transactivating complex pathway
Meiosis pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
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KEGG |
Systemic lupus erythematosus pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q16695 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 8290 | ||||||||||||||||||
UniGene | Hs.248171 | ||||||||||||||||||
RefSeq | NM_003493 | ||||||||||||||||||
HUGO | HGNC:4778 | ||||||||||||||||||
OMIM | 602820 | ||||||||||||||||||
CCDS | CCDS1572 | ||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AF531308 AK312217 AL139288 BC069079 BC101837 BC101839 CH471098 CR542013 Z49861 | ||||||||||||||||||
GenPept | AAH69079 AAI01838 AAI01840 AAN39284 BAG35150 CAA90020 CAG46810 CAI23333 EAW69877 | ||||||||||||||||||
RNA Seq Atlas | 8290 | ||||||||||||||||||