Version 5.4
Homo sapiens Gene: SLC24A5
Summary
InnateDB Gene IDBG-10776.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC24A5
Gene Name solute carrier family 24, member 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000188467
Encoded Proteins
IDBP-10778
solute carrier family 24, member 5
IDBP-371887
solute carrier family 24, member 5
IDBP-600170
solute carrier family 24, member 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the potassium-dependent sodium/calcium exchanger family and encodes an intracellular membrane protein with 2 large hydrophilic loops and 2 sets of multiple transmembrane-spanning segments. Sequence variation in this gene has been associated with differences in skin pigmentation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:48120972-48142672
Strand Forward strand
Band q21.1
Transcripts
ENST00000341459 ENSP00000341550
ENST00000449382 ENSP00000389966
ENST00000482911 ENSP00000453395
ENST00000463289
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008273 calcium, potassium:sodium antiporter activity
GO:0015293 symporter activity
Biological Process
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0006816 calcium ion transport
GO:0034220 ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0048022 negative regulation of melanin biosynthetic process
GO:0050896 response to stimulus
GO:0055085 transmembrane transport
Cellular Component
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0042470 melanosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035183
View Gene Order
ENSBTAG00000004854
Not yet available
Pathways
NETPATH
REACTOME
REACT_19320
Sodium/Calcium exchangers pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H0YLZ0
UniProt Splice Variant
Entrez Gene 283652
UniGene Hs.710240
RefSeq NM_205850 XM_005254308
HUGO HGNC:20611
OMIM 609802
CCDS CCDS10128
HPRD 18055
IMGT
EMBL AC090526
GenPept
RNA Seq Atlas 283652

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca