Version 5.4
Homo sapiens Gene: SMYD3
Summary
InnateDB Gene IDBG-107832.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMYD3
Gene Name SET and MYND domain containing 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000185420
Encoded Proteins
IDBP-246887
SET and MYND domain containing 3
IDBP-295755
SET and MYND domain containing 3
IDBP-390221
SET and MYND domain containing 3
IDBP-390222
SET and MYND domain containing 3
IDBP-474107
SET and MYND domain containing 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:245749342-246507312
Strand Reverse strand
Band q44
Transcripts
ENST00000366517
ENST00000366516
ENST00000391836 ENSP00000375712
ENST00000403792 ENSP00000385380
ENST00000453676 ENSP00000408122
ENST00000455277 ENSP00000394281
ENST00000490107 ENSP00000419184
ENST00000482592
ENST00000483072
ENST00000470510
ENST00000490322
ENST00000493441
ENST00000488153
ENST00000492487
ENST00000464398
ENST00000462422
ENST00000470863
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000993 RNA polymerase II core binding
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0005515 protein binding
GO:0018024 histone-lysine N-methyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006334 nucleosome assembly
GO:0006469 negative regulation of protein kinase activity
GO:0014904 myotube cell development
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034968 histone lysine methylation
GO:0045184 establishment of protein localization
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0071549 cellular response to dexamethasone stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000055067
View Gene Order
ENSBTAG00000033180
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.567571 Hs.677453
RefSeq NM_001167740 NM_022743 XM_005273228
HUGO
OMIM
CCDS CCDS31083
HPRD 12297
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca