Homo sapiens Gene: PLA2G15
Summary
InnateDB Gene IDBG-107914.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol PLA2G15
Gene Name phospholipase A2 group XV
Synonyms ACS; GXVPLA2; LLPL; LPLA2; LYPLA3
Species Homo sapiens
Ensembl Gene ENSG00000103066
Encoded Proteins
phospholipase A2 group XV
phospholipase A2 group XV
phospholipase A2 group XV
phospholipase A2 group XV
phospholipase A2 group XV
phospholipase A2 group XV
phospholipase A2 group XV
phospholipase A2 group XV
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:68245304-68261062
Strand Forward strand
Band q22.1
Transcripts
ENST00000219345 ENSP00000219345
ENST00000413021 ENSP00000394197
ENST00000444212 ENSP00000393610
ENST00000562449
ENST00000562966
ENST00000564827 ENSP00000455461
ENST00000565460
ENST00000565744 ENSP00000454227
ENST00000566188 ENSP00000457034
ENST00000566978 ENSP00000457049
ENST00000568082 ENSP00000454557
ENST00000568599
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004622 lysophospholipase activity
GO:0005543 phospholipid binding
GO:0008374 O-acyltransferase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0016787 hydrolase activity
GO:0047499 calcium-independent phospholipase A2 activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006644 phospholipid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0006672 ceramide metabolic process
GO:0009062 fatty acid catabolic process
GO:0016042 lipid catabolic process
GO:0034638 phosphatidylcholine catabolic process
GO:0046338 phosphatidylethanolamine catabolic process
GO:0046470 phosphatidylcholine metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular exosome
Orthologs
Species
Bos taurus
Mus musculus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Phospholipid metabolism pathway
Metabolism of lipids pathway
Hydrolysis of LPC pathway
Metabolism pathway
Glycerophospholipid biosynthesis pathway
KEGG
Glycerophospholipid metabolism pathway
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt Q8NCC3
TrEMBL B4DJW4 B4DPU0 H3BM47 H3BMU8 H3BPT3 H3BT70
UniProt Splice Variant
Entrez Gene 23659
UniGene
RefSeq NM_012320 XM_005255886 XM_011522979 XM_011522980
HUGO HGNC:17163
OMIM 609362
CCDS CCDS10864
HPRD
IMGT
EMBL AB017494 AC020978 AK001705 AK074828 AK222790 AK296263 AK298494 AK300596 AL110209 AL389957 AY358425 BC011640 BC062605 CH471092
GenPept AAH11640 AAH62605 AAQ88791 BAA76877 BAC11233 BAD96510 BAG50965 BAG58976 BAG60702 BAG62293 CAB53675 CAB97531 EAW83217
RNA Seq Atlas 23659