InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DUT

Summary

InnateDB Gene

IDBG-10926.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUT

Gene Name

deoxyuridine triphosphatase

Synonyms

dUTPase

Species

Homo sapiens

Ensembl Gene

ENSG00000128951

Encoded Proteins

IDBP-10928

deoxyuridine triphosphatase

IDBP-372045

deoxyuridine triphosphatase

IDBP-591089

deoxyuridine triphosphatase

IDBP-602833

deoxyuridine triphosphatase

IDBP-589672

deoxyuridine triphosphatase

IDBP-590533

deoxyuridine triphosphatase

IDBP-592502

deoxyuridine triphosphatase

IDBP-584682

deoxyuridine triphosphatase

IDBP-598891

deoxyuridine triphosphatase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:48331011-48343373

Strand

Forward strand

Band

q21.1

Transcripts

ENST00000331200	ENSP00000370376
ENST00000455976	ENSP00000405160
ENST00000559935	ENSP00000453667
ENST00000559416	ENSP00000454183
ENST00000558813	ENSP00000453717
ENST00000558472	ENSP00000452749
ENST00000558978	ENSP00000452814
ENST00000559540	ENSP00000454041
ENST00000558367	ENSP00000453683
ENST00000561350
ENST00000559852

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	17 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004170	dUTP diphosphatase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006206	pyrimidine nucleobase metabolic process
GO:0006226	dUMP biosynthetic process
GO:0006260	DNA replication
GO:0044281	small molecule metabolic process
GO:0046080	dUTP metabolic process
GO:0046134	pyrimidine nucleoside biosynthetic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005739	mitochondrion
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027203

View Gene Order

ENSBTAG00000011998

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa00240

Pyrimidine metabolism pathway

INOH

INOH website

Pyrimidine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

P33316

TrEMBL

UniProt Splice Variant

Entrez Gene

1854

UniGene

Hs.527980 Hs.707399

RefSeq

NM_001025249 NM_001025248 NM_001948

HUGO

HGNC:3078

OMIM

601266

CCDS

CCDS45256 CCDS32231 CCDS45255

HPRD

03165

IMGT

EMBL

AB049113 AF018429 AF018430 AF018431 AF018432 AK291515 AK298464 AK312122 AY935242 BC033645 BC070339 BC110377 CH471082 CR541720 CR541781 L11877 M89913 U31930 U62891 U90223 U90224

GenPept

AAA36801 AAA58444 AAB71393 AAB71394 AAB93866 AAB93867 AAB94642 AAC50418 AAC51123 AAH33645 AAH70339 AAI10378 AAX14045 BAB13724 BAF84204 BAG35058 BAG60677 CAG46521 CAG46580 EAW77350

RNA Seq Atlas

1854