Version 5.4
Homo sapiens Gene: SORBS3
Summary
InnateDB Gene IDBG-10978.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SORBS3
Gene Name sorbin and SH3 domain containing 3
Synonyms SCAM-1; SCAM1; SH3D4
Species Homo sapiens
Ensembl Gene ENSG00000120896
Encoded Proteins
IDBP-10980
sorbin and SH3 domain containing 3
IDBP-476643
sorbin and SH3 domain containing 3
IDBP-479932
sorbin and SH3 domain containing 3
IDBP-482433
sorbin and SH3 domain containing 3
IDBP-483337
sorbin and SH3 domain containing 3
IDBP-475500
sorbin and SH3 domain containing 3
IDBP-481576
sorbin and SH3 domain containing 3
IDBP-482228
sorbin and SH3 domain containing 3
IDBP-480127
sorbin and SH3 domain containing 3
IDBP-478073
sorbin and SH3 domain containing 3
IDBP-474108
sorbin and SH3 domain containing 3
IDBP-479464
sorbin and SH3 domain containing 3
IDBP-484531
sorbin and SH3 domain containing 3
IDBP-477407
sorbin and SH3 domain containing 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein\'s ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:22544986-22575788
Strand Forward strand
Band p21.3
Transcripts
ENST00000240123 ENSP00000240123
ENST00000522037
ENST00000523941
ENST00000517500 ENSP00000429723
ENST00000517535
ENST00000523402 ENSP00000429685
ENST00000520563 ENSP00000428102
ENST00000524057 ENSP00000428051
ENST00000518512
ENST00000520574
ENST00000521787
ENST00000523740
ENST00000522315
ENST00000519453
ENST00000523900 ENSP00000431128
ENST00000518912 ENSP00000429887
ENST00000523965 ENSP00000429764
ENST00000521554 ENSP00000429058
ENST00000522721 ENSP00000429479
ENST00000523348 ENSP00000428678
ENST00000517962 ENSP00000428327
ENST00000520207 ENSP00000429747
ENST00000519127 ENSP00000428930
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 47 [view]
Protein-Protein 47 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0017166 vinculin binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006936 muscle contraction
GO:0007015 actin filament organization
GO:0007155 cell adhesion
GO:0031589 cell-substrate adhesion
GO:0043410 positive regulation of MAPK cascade
GO:0051495 positive regulation of cytoskeleton organization
GO:0051496 positive regulation of stress fiber assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022091
View Gene Order
ENSBTAG00000014401
Not yet available
Pathways
NETPATH
REACTOME
REACT_20558
Smooth Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.528572 Hs.624907
RefSeq NM_001018003 NM_005775 XM_006716267
HUGO
OMIM
CCDS CCDS6031
HPRD 11535
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca