Version 5.4
Homo sapiens Gene: CRHR2
Summary
InnateDB Gene IDBG-11186.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRHR2
Gene Name corticotropin releasing hormone receptor 2
Synonyms CRF-RB; CRF2; CRFR2; HM-CRF
Species Homo sapiens
Ensembl Gene ENSG00000106113
Encoded Proteins
IDBP-11190
corticotropin releasing hormone receptor 2
IDBP-11192
corticotropin releasing hormone receptor 2
IDBP-370757
corticotropin releasing hormone receptor 2
IDBP-370783
corticotropin releasing hormone receptor 2
IDBP-370784
corticotropin releasing hormone receptor 2
IDBP-473744
corticotropin releasing hormone receptor 2
IDBP-473357
corticotropin releasing hormone receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:30651943-30700129
Strand Reverse strand
Band p14.3
Transcripts
ENST00000348438 ENSP00000340943
ENST00000341843 ENSP00000344304
ENST00000452278 ENSP00000401930
ENST00000445981 ENSP00000401241
ENST00000423776 ENSP00000416620
ENST00000471646 ENSP00000418722
ENST00000462882
ENST00000506074 ENSP00000426498
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0015056 corticotrophin-releasing factor receptor activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0016525 negative regulation of angiogenesis
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0043951 negative regulation of cAMP-mediated signaling
GO:0071376 cellular response to corticotropin-releasing hormone stimulus
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003476
View Gene Order
ENSBTAG00000014381
Not yet available
Pathways
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F2Z2M6
UniProt Splice Variant
Entrez Gene 1395
UniGene Hs.729970
RefSeq NM_001202475 NM_001202481 NM_001202482 NM_001202483 NM_001883 XM_006715651
HUGO HGNC:2358
OMIM 602034
CCDS CCDS5429 CCDS56477 CCDS56478 CCDS75576
HPRD 03614
IMGT
EMBL AC004976
GenPept
RNA Seq Atlas 1395

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca