Version 5.4
Homo sapiens Gene: NUP50
Summary
InnateDB Gene IDBG-11282.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUP50
Gene Name nucleoporin 50kDa
Synonyms NPAP60; NPAP60L
Species Homo sapiens
Ensembl Gene ENSG00000093000
Encoded Proteins
IDBP-11284
nucleoporin 50kDa
IDBP-238212
nucleoporin 50kDa
IDBP-295685
nucleoporin 50kDa
IDBP-379665
nucleoporin 50kDa
IDBP-379667
nucleoporin 50kDa
IDBP-379668
nucleoporin 50kDa
IDBP-379670
nucleoporin 50kDa
IDBP-379671
nucleoporin 50kDa
IDBP-379672
nucleoporin 50kDa
IDBP-379675
nucleoporin 50kDa
IDBP-379676
nucleoporin 50kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:45163841-45188015
Strand Forward strand
Band q13.31
Transcripts
ENST00000347635 ENSP00000345895
ENST00000396096 ENSP00000379403
ENST00000407019 ENSP00000385555
ENST00000424634 ENSP00000415062
ENST00000417702 ENSP00000394450
ENST00000430547 ENSP00000397960
ENST00000434760 ENSP00000388426
ENST00000445721 ENSP00000398297
ENST00000432340 ENSP00000400465
ENST00000419387 ENSP00000391987
ENST00000422489 ENSP00000416264
ENST00000497960
ENST00000461437
ENST00000484186
ENST00000493456
ENST00000461194
ENST00000486184
ENST00000491860
ENST00000469163
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 30 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0005975 carbohydrate metabolic process
GO:0007077 mitotic nuclear envelope disassembly
GO:0008645 hexose transport
GO:0010827 regulation of glucose transport
GO:0015031 protein transport
GO:0015758 glucose transport
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0044281 small molecule metabolic process
GO:0046907 intracellular transport
GO:0051028 mRNA transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000016619
View Gene Order
ENSBTAG00000017652
Not yet available
Pathways
NETPATH
REACTOME
REACT_115831
ISG15 antiviral mechanism pathway
REACT_6804
Regulation of Glucokinase by Glucokinase Regulatory Protein pathway
REACT_212
Glucose transport pathway
REACT_9441
Hexose transport pathway
REACT_9395
Nuclear import of Rev protein pathway
REACT_7991
Vpr-mediated nuclear import of PICs pathway
REACT_6190
Rev-mediated nuclear export of HIV RNA pathway
REACT_6354
Viral Messenger RNA Synthesis pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_6167
Influenza Infection pathway
REACT_6757
Interactions of Vpr with host cellular proteins pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_267668
Transcriptional regulation by small RNAs pathway
REACT_163931
Nuclear Pore Complex (NPC) Disassembly pathway
REACT_6152
Influenza Viral RNA Transcription and Replication pathway
REACT_25229
Interferon Signaling pathway
REACT_115566
Cell Cycle pathway
REACT_6900
Immune System pathway
REACT_910
M Phase pathway
REACT_6256
HIV Life Cycle pathway
REACT_765
Mitotic Prophase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_6185
HIV Infection pathway
REACT_6145
Influenza Life Cycle pathway
REACT_111217
Metabolism pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_6916
Interactions of Rev with host cellular proteins pathway
REACT_71
Gene Expression pathway
REACT_160255
Nuclear Envelope Breakdown pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
REACT_12472
Regulatory RNA pathways pathway
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.630807 Hs.731619 Hs.739648
RefSeq NM_007172 NM_153645 XM_005261313 XM_006724103 XM_006724104
HUGO
OMIM
CCDS CCDS14062 CCDS14063
HPRD 05226
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca