InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADCYAP1R1

Summary

InnateDB Gene

IDBG-11429.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADCYAP1R1

Gene Name

adenylate cyclase activating polypeptide 1 (pituitary) receptor type I

Synonyms

PAC1; PAC1R; PACAPR; PACAPRI

Species

Homo sapiens

Ensembl Gene

ENSG00000078549

Encoded Proteins

IDBP-11431

adenylate cyclase activating polypeptide 1 (pituitary) receptor type I

IDBP-237965

adenylate cyclase activating polypeptide 1 (pituitary) receptor type I

IDBP-294438

adenylate cyclase activating polypeptide 1 (pituitary) receptor type I

IDBP-294436

adenylate cyclase activating polypeptide 1 (pituitary) receptor type I

IDBP-371056

adenylate cyclase activating polypeptide 1 (pituitary) receptor type I

IDBP-371065

adenylate cyclase activating polypeptide 1 (pituitary) receptor type I

IDBP-807327

adenylate cyclase activating polypeptide 1 (pituitary) receptor type I

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:31052461-31111479

Strand

Forward strand

Band

p14.3

Transcripts

ENST00000304166	ENSP00000306620
ENST00000396211	ENSP00000379514
ENST00000409363	ENSP00000387335
ENST00000409489	ENSP00000386395
ENST00000431811	ENSP00000400893
ENST00000436116	ENSP00000416622
ENST00000614107	ENSP00000483721

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004999	vasoactive intestinal polypeptide receptor activity
GO:0005515	protein binding
GO:0008179	adenylate cyclase binding
GO:0030306	ADP-ribosylation factor binding
GO:0042923	neuropeptide binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007202	activation of phospholipase C activity
GO:0007283	spermatogenesis
GO:0010524	positive regulation of calcium ion transport into cytosol
GO:0019933	cAMP-mediated signaling
GO:0030154	cell differentiation
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0032355	response to estradiol
GO:0033555	multicellular organismal response to stress
GO:0042493	response to drug
GO:0045471	response to ethanol
GO:0046545	development of primary female sexual characteristics
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0060548	negative regulation of cell death
GO:0060732	positive regulation of inositol phosphate biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005791	rough endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005901	caveola
GO:0005923	tight junction
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043005	neuron projection
GO:0043235	receptor complex