Version 5.4
| Homo sapiens Gene: TNFRSF10C | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-11572.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | TNFRSF10C | ||||||||||||||||||
| Gene Name | tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain | ||||||||||||||||||
| Synonyms | CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3; TRAILR3; TRID | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000173535 | ||||||||||||||||||
| Encoded Proteins |
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 8:23084355-23117437 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | p21.3 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME | |||||||||||||||||||
| KEGG |
Apoptosis pathway
Cytokine-cytokine receptor interaction pathway
Natural killer cell mediated cytotoxicity pathway
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| INOH | |||||||||||||||||||
| PID NCI |
TRAIL signaling pathway
Direct p53 effectors
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| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | E9PBT0 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 8794 | ||||||||||||||||||
| UniGene | Hs.655801 Hs.735240 | ||||||||||||||||||
| RefSeq | NM_003841 | ||||||||||||||||||
| HUGO | HGNC:11906 | ||||||||||||||||||
| OMIM | 603613 | ||||||||||||||||||
| CCDS | CCDS6037 | ||||||||||||||||||
| HPRD | 04681 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC107959 | ||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | 8794 | ||||||||||||||||||