InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: USP8

Summary

InnateDB Gene

IDBG-11726.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP8

Gene Name

ubiquitin specific peptidase 8

Synonyms

HumORF8; SPG59; UBPY

Species

Homo sapiens

Ensembl Gene

ENSG00000138592

Encoded Proteins

IDBP-11728

ubiquitin specific peptidase 8

IDBP-237470

ubiquitin specific peptidase 8

IDBP-372485

ubiquitin specific peptidase 8

IDBP-591298

ubiquitin specific peptidase 8

IDBP-587020

ubiquitin specific peptidase 8

IDBP-603815

ubiquitin specific peptidase 8

IDBP-590214

ubiquitin specific peptidase 8

IDBP-745317

IDBP-590236

ubiquitin specific peptidase 8

IDBP-596055

ubiquitin specific peptidase 8

IDBP-593102

ubiquitin specific peptidase 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that belongs to the ubiquitin-specific processing protease family of proteins. The encoded protein is thought to regulate the morphology of the endosome by ubiquitination of proteins on this organelle and is involved in cargo sorting and membrane trafficking at the early endosome stage. This protein is required for the cell to enter the S phase of the cell cycle and also functions as a positive regulator in the Hedgehog signaling pathway in development. Pseudogenes of this gene are present on chromosomes 2 and 6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:50424380-50514419

Strand

Forward strand

Band

q21.2

Transcripts

ENST00000307179	ENSP00000302239
ENST00000396444	ENSP00000379721
ENST00000425032	ENSP00000412682
ENST00000419830
ENST00000560297	ENSP00000453206
ENST00000560954
ENST00000558892
ENST00000560885
ENST00000559329	ENSP00000454003
ENST00000560730	ENSP00000452950
ENST00000560982	ENSP00000453427
ENST00000561211	ENSP00000457345
ENST00000558091	ENSP00000454059
ENST00000559242	ENSP00000453320
ENST00000561330	ENSP00000453460
ENST00000560527
ENST00000561206
ENST00000560379

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	81 [view]
Protein-Protein	81 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0000281	mitotic cytokinesis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007032	endosome organization
GO:0007265	Ras protein signal transduction
GO:0008283	cell proliferation
GO:0016579	protein deubiquitination
GO:0070536	protein K63-linked deubiquitination
GO:0071108	protein K48-linked deubiquitination

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0019897	extrinsic component of plasma membrane
GO:0030496	midbody