Version 5.4
Homo sapiens Gene: DHX15
Summary
InnateDB Gene IDBG-11833.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DHX15
Gene Name DEAH (Asp-Glu-Ala-His) box polypeptide 15
Synonyms DBP1; DDX15; HRH2; PRP43; PRPF43; PrPp43p
Species Homo sapiens
Ensembl Gene ENSG00000109606
Encoded Proteins
IDBP-11835
DEAH (Asp-Glu-Ala-His) box polypeptide 15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 26494172
[Mus musculus] Nlrp6 functions with Dhx15 as a viral RNA sensor to induce IFN-stimulated genes, and this effect is especially important in the intestinal tract.
Entrez Gene
Summary The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:24517441-24584550
Strand Reverse strand
Band p15.2
Transcripts
ENST00000336812 ENSP00000336741
ENST00000510645
ENST00000508032
ENST00000512903
ENST00000513036
ENST00000508368
ENST00000504279
ENST00000503562
ENST00000511553
ENST00000513092
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 153 experimentally validated interaction(s) in this database.
Experimentally validated
Total 153 [view]
Protein-Protein 153 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0003725 double-stranded RNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005689 U12-type spliceosomal complex
GO:0005730 nucleolus
GO:0071008 U2-type post-mRNA release spliceosomal complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029169
View Gene Order
ENSBTAG00000008896
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.666974 Hs.696074
RefSeq NM_001358
HUGO
OMIM
CCDS CCDS33966
HPRD 04553
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca