InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYP19A1

Summary

InnateDB Gene

IDBG-11985.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP19A1

Gene Name

cytochrome P450, family 19, subfamily A, polypeptide 1

Synonyms

ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM

Species

Homo sapiens

Ensembl Gene

ENSG00000137869

Encoded Proteins

IDBP-11987

cytochrome P450, family 19, subfamily A, polypeptide 1

IDBP-237565

cytochrome P450, family 19, subfamily A, polypeptide 1

IDBP-237567

cytochrome P450, family 19, subfamily A, polypeptide 1

IDBP-294292

cytochrome P450, family 19, subfamily A, polypeptide 1

IDBP-294291

cytochrome P450, family 19, subfamily A, polypeptide 1

IDBP-372703

cytochrome P450, family 19, subfamily A, polypeptide 1

IDBP-372715

cytochrome P450, family 19, subfamily A, polypeptide 1

IDBP-586804

cytochrome P450, family 19, subfamily A, polypeptide 1

IDBP-601643

cytochrome P450, family 19, subfamily A, polypeptide 1

IDBP-590873

cytochrome P450, family 19, subfamily A, polypeptide 1

IDBP-593251

cytochrome P450, family 19, subfamily A, polypeptide 1

IDBP-602827

cytochrome P450, family 19, subfamily A, polypeptide 1

IDBP-588744

cytochrome P450, family 19, subfamily A, polypeptide 1

IDBP-586285

cytochrome P450, family 19, subfamily A, polypeptide 1

IDBP-600969

cytochrome P450, family 19, subfamily A, polypeptide 1

IDBP-807105

cytochrome P450, family 19, subfamily A, polypeptide 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. [provided by RefSeq, Jul 2008]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:51208057-51338610

Strand

Reverse strand

Band

q21.2

Transcripts

ENST00000260433	ENSP00000260433
ENST00000396404	ENSP00000379685
ENST00000396402	ENSP00000379683
ENST00000405913	ENSP00000383930
ENST00000405011	ENSP00000384389
ENST00000439712	ENSP00000390614
ENST00000453807	ENSP00000391139
ENST00000490076
ENST00000478421
ENST00000492852
ENST00000559878	ENSP00000453149
ENST00000559653	ENSP00000452667
ENST00000557934	ENSP00000454004
ENST00000558066
ENST00000561075	ENSP00000454039
ENST00000558328	ENSP00000453280
ENST00000557858	ENSP00000452627
ENST00000559980	ENSP00000452872
ENST00000559646	ENSP00000453318
ENST00000561066
ENST00000613097	ENSP00000479587

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	2 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0009055	electron carrier activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825	oxygen binding
GO:0020037	heme binding
GO:0070330	aromatase activity

Biological Process

GO:0006694	steroid biosynthetic process
GO:0006703	estrogen biosynthetic process
GO:0006805	xenobiotic metabolic process
GO:0008202	steroid metabolic process
GO:0008209	androgen metabolic process
GO:0016125	sterol metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0060736	prostate gland growth