Version 5.4
Homo sapiens Gene: ADAMTS5
Summary
InnateDB Gene IDBG-1207.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAMTS5
Gene Name ADAM metallopeptidase with thrombospondin type 1 motif, 5
Synonyms ADAM-TS 11; ADAM-TS 5; ADAM-TS5; ADAMTS-11; ADAMTS-5; ADAMTS11; ADMP-2
Species Homo sapiens
Ensembl Gene ENSG00000154736
Encoded Proteins
IDBP-1209
ADAM metallopeptidase with thrombospondin type 1 motif, 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:26917912-26966513
Strand Reverse strand
Band q21.3
Transcripts
ENST00000284987 ENSP00000284987
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0042742 defense response to bacterium
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022894
View Gene Order
ENSBTAG00000000648
Not yet available
Pathways
NETPATH
REACTOME
REACT_22161
Post-translational protein modification pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_200727
O-linked glycosylation pathway
REACT_17015
Metabolism of proteins pathway
REACT_200626
O-glycosylation of TSR domain-containing proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9UNA0
TrEMBL
UniProt Splice Variant
Entrez Gene 11096
UniGene Hs.58324 Hs.609148 Hs.617225
RefSeq NM_007038
HUGO HGNC:221
OMIM 605007
CCDS CCDS13579
HPRD
IMGT
EMBL AF141293 AF142099 AP001697 AP001698 BC093775 BC093777
GenPept AAD49577 AAF02493 AAH93775 AAH93777 BAA95503 BAA95504
RNA Seq Atlas 11096

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca