Version 5.4
Homo sapiens Gene: DMXL2
Summary
InnateDB Gene IDBG-12130.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DMXL2
Gene Name Dmx-like 2
Synonyms RC3
Species Homo sapiens
Ensembl Gene ENSG00000104093
Encoded Proteins
IDBP-12132
Dmx-like 2
IDBP-372809
Dmx-like 2
IDBP-583750
Dmx-like 2
IDBP-596656
Dmx-like 2
IDBP-592318
Dmx-like 2
IDBP-589723
Dmx-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with 12 WD domains. Proteins with WD domains are involved in many functions including participation in signal transduction pathways. Participation of the encoded protein in regulation of the Notch signaling pathway has been demonstrated in vitro using several human cell lines (PMID:20810660). A gene encoding a similar protein is located on chromosome 5. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:51447711-51622833
Strand Reverse strand
Band q21.2
Transcripts
ENST00000251076 ENSP00000251076
ENST00000449909 ENSP00000400855
ENST00000560891 ENSP00000453267
ENST00000543779 ENSP00000441858
ENST00000559769
ENST00000559059 ENSP00000453570
ENST00000559868
ENST00000559062
ENST00000558124
ENST00000560211
ENST00000559498 ENSP00000453454
ENST00000561079
ENST00000560421
ENST00000558507
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017137 Rab GTPase binding
Biological Process
Cellular Component
GO:0005615 extracellular space
GO:0008021 synaptic vesicle
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041268
View Gene Order
ENSBTAG00000000737
Not yet available
Cross-References
SwissProt Q8TDJ6
TrEMBL A0A024R5V2 H0YME1
UniProt Splice Variant
Entrez Gene 23312
UniGene Hs.511386 Hs.725363
RefSeq NM_001174116 NM_001174117 NM_015263 XM_005254257 XM_005254258 XM_006720446
HUGO HGNC:2938
OMIM 612186
CCDS CCDS10141 CCDS53945 CCDS53946
HPRD
IMGT
EMBL AB020663 AC020892 AC066613 AF389880 BC140781 BC144539 CH471082
GenPept AAI40782 AAI44540 AAL93215 BAA74879 EAW77422 EAW77423
RNA Seq Atlas 23312

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca