Version 5.4
Homo sapiens Gene: SCG3
Summary
InnateDB Gene IDBG-12183.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCG3
Gene Name secretogranin III
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000104112
Encoded Proteins
IDBP-12185
secretogranin III
IDBP-584565
secretogranin III
IDBP-591337
secretogranin III
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:51681353-51721031
Strand Forward strand
Band q21.2
Transcripts
ENST00000220478 ENSP00000220478
ENST00000542355 ENSP00000445205
ENST00000558709 ENSP00000452745
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
Biological Process
GO:0002576 platelet degranulation
GO:0007596 blood coagulation
GO:0030168 platelet activation
Cellular Component
GO:0005576 extracellular region
GO:0030658 transport vesicle membrane
GO:0034774 secretory granule lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032181
View Gene Order
ENSBTAG00000017677
Not yet available
Pathways
NETPATH
REACTOME
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H0YKC2
UniProt Splice Variant
Entrez Gene 29106
UniGene Hs.232618
RefSeq NM_001165257 NM_013243
HUGO HGNC:13707
OMIM 611796
CCDS CCDS10142 CCDS53947
HPRD 11538
IMGT
EMBL AC020892
GenPept
RNA Seq Atlas 29106

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca