Homo sapiens Gene: TERC
Summary
InnateDB Gene IDBG-122203.4
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol TERC
Gene Name telomerase RNA component
Synonyms DKCA1; hTR; PFBMFT2; SCARNA19; TR; TRC3;
Species Homo sapiens
Ensembl Gene ENSG00000200182
Encoded Proteins
Protein Structure
Entrez Gene
Summary Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component, encoded by this gene, that serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Mutations in this gene cause autosomal dominant dyskeratosis congenita, and may also be associated with some cases of aplastic anemia. [provided by RefSeq, Jul 2008]
Gene Information
Type misc_RNA
Genomic Location Chromosome 3:169482398-169482835
Strand Reverse strand
Band q26.2
Transcripts
ENST00000363312
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 3 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 7012
UniGene Hs.436182
RefSeq
HUGO 11727
OMIM 602322
CCDS
HPRD
IMGT
EMBL
GenPept
ImmGen TERC (murine)
RNA Seq Atlas 7012