Version 5.4
Homo sapiens Gene: TPTE2
Summary
InnateDB Gene IDBG-12255.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPTE2
Gene Name transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000132958
Encoded Proteins
IDBP-12257
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
IDBP-12259
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
IDBP-12261
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
IDBP-12267
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
IDBP-228708
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
IDBP-229038
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
IDBP-591194
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary TPIP is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.[supplied by OMIM, Jul 2002]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:19422877-19536762
Strand Reverse strand
Band q12.11
Transcripts
ENST00000382978 ENSP00000372438
ENST00000382977 ENSP00000372437
ENST00000390680 ENSP00000375098
ENST00000255310 ENSP00000255310
ENST00000400230 ENSP00000383089
ENST00000400103 ENSP00000382974
ENST00000462409 ENSP00000432402
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005216 ion channel activity
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006811 ion transport
GO:0016311 dephosphorylation
GO:0034220 ion transmembrane transport
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0044281 small molecule metabolic process
GO:0055085 transmembrane transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_120836
Synthesis of PIPs at the Golgi membrane pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.377488
RefSeq NM_001141968 NM_130785 NM_199254
HUGO
OMIM
CCDS CCDS45013 CCDS45014 CCDS9285
HPRD 06003
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca