Version 5.4
Homo sapiens Gene: GZMM
Summary
InnateDB Gene IDBG-12497.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GZMM
Gene Name granzyme M (lymphocyte met-ase 1)
Synonyms LMET1; MET1
Species Homo sapiens
Ensembl Gene ENSG00000197540
Encoded Proteins
IDBP-12499
granzyme M (lymphocyte met-ase 1)
IDBP-810861
granzyme M (lymphocyte met-ase 1)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20406824
GZMM (granzyme M) cleaves BIRC5 and this triggers degradation of the BIRC5-XIAP complex to free caspase activity, leading to cytolysis of target cells.
PMID 21979465
GZMM cleaves FADD to potentiate the killing efficacy of innate effector natural killer cells against tumor cells and intracellular pathogens.
InnateDB Annotation from Orthologs
Summary
PMID 21979465
[Mus musculus] Gzmm cleaves Fadd to potentiate the killing efficacy of innate effector natural killer cells against tumor cells and intracellular pathogens. (Demonstrated in human)
Entrez Gene
Summary Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:544034-549924
Strand Forward strand
Band p13.3
Transcripts
ENST00000264553 ENSP00000264553
ENST00000592501 ENSP00000476255
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0019835 cytolysis
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054206
View Gene Order
ENSBTAG00000002100
Not yet available
Pathways
NETPATH
REACTOME
REACT_8001
Alternative complement activation pathway
REACT_8024
Initial triggering of complement pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_6932
Complement cascade pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 3004
UniGene
RefSeq NM_001258351 NM_005317
HUGO HGNC:4712
OMIM 600311
CCDS CCDS74240 CCDS12031
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 3004

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca