Version 5.4
Homo sapiens Gene: POLRMT
Summary
InnateDB Gene IDBG-12581.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLRMT
Gene Name polymerase (RNA) mitochondrial (DNA directed)
Synonyms APOLMT; h-mtRPOL; MTRNAP; MTRPOL
Species Homo sapiens
Ensembl Gene ENSG00000099821
Encoded Proteins
IDBP-761808
IDBP-762619
IDBP-808400
polymerase (RNA) mitochondrial (DNA directed)
IDBP-764763
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:617223-633604
Strand Reverse strand
Band p13.3
Transcripts
ENST00000590573 ENSP00000466504
ENST00000592633
ENST00000588649 ENSP00000465759
ENST00000589961
ENST00000592863 ENSP00000473524
ENST00000587057
ENST00000590336 ENSP00000468658
ENST00000590709
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 13 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003899 DNA-directed RNA polymerase activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006390 transcription from mitochondrial promoter
GO:0006391 transcription initiation from mitochondrial promoter
GO:0010467 gene expression
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0042645 mitochondrial nucleoid
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020329
View Gene Order
ENSBTAG00000015051
Not yet available
Pathways
NETPATH
REACTOME
REACT_367
Mitochondrial transcription initiation pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_1484
Transcription from mitochondrial promoters pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.254113
RefSeq NM_005035 XM_005259580
HUGO
OMIM
CCDS CCDS12036
HPRD 03468
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca