InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PGF

Summary

InnateDB Gene

IDBG-12625.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PGF

Gene Name

placental growth factor

Synonyms

D12S1900; PGFL; PLGF; PlGF-2; SHGC-10760

Species

Homo sapiens

Ensembl Gene

ENSG00000119630

Encoded Proteins

IDBP-12629

placental growth factor

IDBP-293102

placental growth factor

IDBP-584581

placental growth factor

IDBP-586268

placental growth factor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:74941834-74955784

Strand

Reverse strand

Band

q24.3

Transcripts

ENST00000238607	ENSP00000238607
ENST00000405431	ENSP00000385365
ENST00000555567	ENSP00000451040
ENST00000553716	ENSP00000451413
ENST00000557748
ENST00000555253
ENST00000556939
ENST00000555234

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008201	heparin binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001666	response to hypoxia
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002040	sprouting angiogenesis
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0007565	female pregnancy
GO:0008284	positive regulation of cell proliferation
GO:0030154	cell differentiation
GO:0031100	organ regeneration
GO:0032870	cellular response to hormone stimulus
GO:0042493	response to drug
GO:0045766	positive regulation of angiogenesis
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0051781	positive regulation of cell division
GO:0060688	regulation of morphogenesis of a branching structure

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000004791

View Gene Order

ENSBTAG00000013688

Not yet available

Pathways

NETPATH

REACTOME

REACT_12583

VEGF binds to VEGFR leading to receptor dimerization pathway

REACT_12380

VEGF ligand-receptor interactions pathway

REACT_12529

Signaling by VEGF pathway

REACT_111102

Signal Transduction pathway

KEGG

hsa04510

Focal adhesion pathway

hsa05200

Pathways in cancer pathway

INOH

PID NCI

vegf_vegfr_pathway

VEGF and VEGFR signaling network

vegfr1_pathway

VEGFR1 specific signals

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.252820 Hs.738487

RefSeq

NM_001207012 NM_001293643 NM_002632 XM_005267761

HUGO

OMIM

CCDS

CCDS55932 CCDS73664 CCDS9835

HPRD

03076

IMGT

EMBL

GenPept

RNA Seq Atlas