Homo sapiens Gene: ELMO1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-12649.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | ELMO1 | ||||||||||||||||||||||
Gene Name | engulfment and cell motility 1 | ||||||||||||||||||||||
Synonyms | CED-12; CED12; ELMO-1 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000155849 | ||||||||||||||||||||||
Encoded Proteins |
engulfment and cell motility 1
engulfment and cell motility 1
engulfment and cell motility 1
engulfment and cell motility 1
engulfment and cell motility 1
engulfment and cell motility 1
engulfment and cell motility 1
engulfment and cell motility 1
engulfment and cell motility 1
engulfment and cell motility 1
engulfment and cell motility 1
engulfment and cell motility 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011] This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 7:36854361-37449249 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | p14.1 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH |
TCR pathway
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REACTOME |
Regulation of actin dynamics for phagocytic cup formation pathway
Nef and signal transduction pathway
Signaling by VEGF pathway
Innate Immune System pathway
Signal Transduction pathway
Immune System pathway
VEGFA-VEGFR2 Pathway pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
HIV Infection pathway
The role of Nef in HIV-1 replication and disease pathogenesis pathway
Host Interactions of HIV factors pathway
Disease pathway
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KEGG |
Chemokine signaling pathway pathway
Bacterial invasion of epithelial cells pathway
Shigellosis pathway
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INOH | |||||||||||||||||||||||
PID NCI |
IL8- and CXCR2-mediated signaling events
Regulation of RAC1 activity
Netrin-mediated signaling events
Signaling events mediated by focal adhesion kinase
Neurotrophic factor-mediated Trk receptor signaling
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Cross-References | |||||||||||||||||||||||
SwissProt | Q92556 | ||||||||||||||||||||||
TrEMBL | A4D1X5 B4DJV6 C9J5X3 C9JB20 C9JIW2 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 9844 | ||||||||||||||||||||||
UniGene | Hs.595812 Hs.656638 Hs.739086 | ||||||||||||||||||||||
RefSeq | NM_001206482 NM_001039459 NM_001206480 NM_014800 NM_130442 XM_005249919 XM_005249920 XM_006715805 | ||||||||||||||||||||||
HUGO | HGNC:16286 | ||||||||||||||||||||||
OMIM | 606420 | ||||||||||||||||||||||
CCDS | CCDS5449 CCDS5450 | ||||||||||||||||||||||
HPRD | 12102 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC007349 AC007444 AC009196 AC078843 AC078844 AC083861 AF398885 AK126565 AK291784 AK296253 AL136787 BC003051 BC064635 BC077074 BC114341 CH236951 CH471073 D87457 | ||||||||||||||||||||||
GenPept | AAH03051 AAH64635 AAH77074 AAI14342 AAL14466 BAA13397 BAC86597 BAF84473 BAG58968 CAB66721 EAL23978 EAL23979 EAW94076 EAW94077 EAW94078 | ||||||||||||||||||||||
RNA Seq Atlas | 9844 | ||||||||||||||||||||||