InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Map3k8

Summary

InnateDB Gene

IDBG-127807.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map3k8

Gene Name

mitogen-activated protein kinase kinase kinase 8

Synonyms

c-COT; Cot; Cot/Tpl2; Est; Estf; Tpl-2; Tpl2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024235

Encoded Proteins

IDBP-127809

mitogen-activated protein kinase kinase kinase 8

IDBP-621137

mitogen-activated protein kinase kinase kinase 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21135874

Map3k8 is a MEK kinase that is require for the activation of MAP kinases in myeloid cells following TLR and TNF receptor stimulation. Map3k8 is critical for production of the pro-inflammatory cytokine TNF during inflammatory responses.

PMID 26241898

Map3k8 plays a role in facilitating both innate and adaptive antiviral responses by transducing Type I interferon (IFN) signals and promoting expression of IFN-stimulated genes (ISGs).

InnateDB Annotation from Orthologs

Summary

PMID 19667062

[Homo sapiens] MAP3K8 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells.

PMID 19933865

[Homo sapiens] MAP3K8 is essential for IL-1beta production from both macrophages and dendritic cells and an important mediator for collaboration of pattern recognition receptors with danger-associated molecular patterns (DAMPs) to induce TNF and IL-1beta production and optimal host defence.

PMID 20405269

[Homo sapiens] MAP3K8 regulates IL23A expression in lipopolysaccharide (LPS)-stimulated macrophages through extracellular signal-regulated kinase (ERK) activation.

PMID 21135874

[Homo sapiens] MAP3K8 is a MEK kinase that is require for the activation of MAP kinases in myeloid cells following TLR and TNF receptor stimulation. MAP3K8 is critical for production of the pro-inflammatory cytokine TNF during inflammatory responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107968:
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:4331327-4353015

Strand

Reverse strand

Band

Transcripts

ENSMUST00000025078	ENSMUSP00000025078
ENSMUST00000105472
ENSMUST00000173930	ENSMUSP00000133469
ENSMUST00000173708
ENSMUST00000172805

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0002376	immune system process
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0035556	intracellular signal transduction
GO:0045087	innate immune response (InnateDB)