InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ONECUT1

Summary

InnateDB Gene

IDBG-12782.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ONECUT1

Gene Name

one cut homeobox 1

Synonyms

HNF-6; HNF6; HNF6A

Species

Homo sapiens

Ensembl Gene

ENSG00000169856

Encoded Proteins

IDBP-12784

one cut homeobox 1

IDBP-585763

one cut homeobox 1

IDBP-807801

one cut homeobox 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:52756989-52791078

Strand

Reverse strand

Band

q21.3

Transcripts

ENST00000305901	ENSP00000302630
ENST00000561401
ENST00000560699	ENSP00000453718
ENST00000570208	ENSP00000476168

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 306 experimentally validated interaction(s) in this database.

Experimentally validated
Total	306 [view]
Protein-Protein	9 [view]
Protein-DNA	296 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001889	liver development
GO:0001952	regulation of cell-matrix adhesion
GO:0002064	epithelial cell development
GO:0006006	glucose metabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007492	endoderm development
GO:0009653	anatomical structure morphogenesis
GO:0030154	cell differentiation
GO:0030183	B cell differentiation
GO:0030335	positive regulation of cell migration
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031016	pancreas development
GO:0031018	endocrine pancreas development
GO:0042384	cilium assembly
GO:0045165	cell fate commitment
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048536	spleen development

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000043013

View Gene Order

ENSBTAG00000046470

Not yet available

Pathways

NETPATH

REACTOME

REACT_13673

Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells pathway

REACT_13778

Regulation of gene expression in early pancreatic precursor cells pathway

REACT_111045

Developmental Biology pathway

REACT_13698

Regulation of beta-cell development pathway

KEGG

hsa04950

Maturity onset diabetes of the young pathway

INOH

PID NCI

foxm1pathway

FOXM1 transcription factor network

Cross-References

SwissProt

Q9UBC0

TrEMBL

B2CNW3

UniProt Splice Variant

Entrez Gene

3175

UniGene

Hs.658573

RefSeq

NM_004498

HUGO

HGNC:8138

OMIM

604164

CCDS

CCDS10150

HPRD

05002

IMGT

EMBL

AF035580 AF035581 BC140830 CH471082 EU532019 U77975 U96173 Y17739

GenPept

AAB61705 AAD00826 AAD02033 AAI40831 ACB30402 CAB50769 EAW77461

RNA Seq Atlas

3175