Version 5.4
Mus musculus Gene: Svil
Summary
InnateDB Gene IDBG-127842.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Svil
Gene Name supervillin
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000024236
Encoded Proteins
IDBP-127844
supervillin
IDBP-541593
supervillin
IDBP-539095
supervillin
IDBP-538876
supervillin
IDBP-534336
supervillin
IDBP-541056
supervillin
IDBP-541598
supervillin
IDBP-532468
supervillin
IDBP-531733
supervillin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197321:
This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Two transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:4920540-5119299
Strand Forward strand
Band A1
Transcripts
ENSMUST00000025079 ENSMUSP00000025079
ENSMUST00000126977 ENSMUSP00000115078
ENSMUST00000131210
ENSMUST00000138258
ENSMUST00000143254 ENSMUSP00000119287
ENSMUST00000153016 ENSMUSP00000121497
ENSMUST00000140448 ENSMUSP00000119803
ENSMUST00000148564
ENSMUST00000127297 ENSMUSP00000115223
ENSMUST00000131609 ENSMUSP00000122242
ENSMUST00000125512 ENSMUSP00000121972
ENSMUST00000139761
ENSMUST00000146723 ENSMUSP00000115591
ENSMUST00000129543
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 63 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0051015 actin filament binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0007519 skeletal muscle tissue development
Cellular Component
GO:0002102 podosome
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
GO:0030054 cell junction
GO:0043034 costamere
GO:0071437 invadopodium
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000197321
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID NCI
ar_pathway
Coregulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.136791 Mm.448198
RefSeq NM_153153 XM_006525783 XM_006525784 XM_006525799
OMIM
CCDS CCDS37720
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca