Version 5.4
Mus musculus Gene: Pomc
Summary
InnateDB Gene IDBG-127850.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pomc
Gene Name pro-opiomelanocortin-alpha
Synonyms ACTH; alpha-MSH; alphaMSH; BE; Beta-LPH; beta-MSH; Clip; Gamma-LPH; gamma-MSH; Npp; Pomc-1; Pomc1
Species Mus musculus
Ensembl Gene ENSMUSG00000020660
Encoded Proteins
IDBP-127852
pro-opiomelanocortin-alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing. Processing yields several biologically active peptides, which are involved in diverse cellular functions, such as energy homeostasis, steroidogenesis, and increased melanin production in melanocytes. In mouse deficiency of this gene is associated with obesity, defects in adrenal development, and altered pigmentation. A pseudogene of this gene is located on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:3954951-3960618
Strand Forward strand
Band A1.1
Transcripts
ENSMUST00000020990 ENSMUSP00000020990
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0005102 receptor binding
GO:0005179 hormone activity
GO:0031781 type 3 melanocortin receptor binding
GO:0031782 type 4 melanocortin receptor binding
GO:0070996 type 1 melanocortin receptor binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0007165 signal transduction
GO:0007218 neuropeptide signaling pathway
GO:0007267 cell-cell signaling
GO:0008217 regulation of blood pressure
GO:0032098 regulation of appetite
GO:0032720 negative regulation of tumor necrosis factor production
GO:0033059 cellular pigmentation
GO:0042593 glucose homeostasis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0070873 regulation of glycogen metabolic process
GO:2000852 regulation of corticosterone secretion
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005782 peroxisomal matrix
GO:0030141 secretory granule
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115138
View Gene Order
ENSBTAG00000007897
Not yet available
Pathways
NETPATH
REACTOME
REACT_232159
Cytochrome P450 - arranged by substrate type pathway
REACT_242871
G alpha (s) signalling events pathway
REACT_223625
GPCR downstream signaling pathway
REACT_249802
Phase 1 - Functionalization of compounds pathway
REACT_207160
Glucocorticoid biosynthesis pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_188937
Metabolism pathway
REACT_247926
Metabolism of proteins pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_227038
Endogenous sterols pathway
REACT_206913
Peptide hormone metabolism pathway
REACT_205726
G-protein activation pathway
REACT_231468
GPCR ligand binding pathway
REACT_220332
Androgen biosynthesis pathway
REACT_235286
Peptide ligand-binding receptors pathway
REACT_250376
G alpha (i) signalling events pathway
REACT_232343
Biological oxidations pathway
REACT_242845
Opioid Signalling pathway
REACT_188257
Signal Transduction pathway
REACT_220061
Metabolism of steroid hormones and vitamin D pathway
REACT_242718
Peptide hormone biosynthesis pathway
KEGG
mmu04916
Melanogenesis pathway
mmu04920
Adipocytokine signaling pathway pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_19327
G alpha (s) signalling events pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_15457
G-protein activation pathway
REACT_15295
Opioid Signalling pathway
REACT_15452
Peptide hormone biosynthesis pathway
REACT_11036
Glucocorticoid biosynthesis pathway
REACT_11059
Androgen biosynthesis pathway
REACT_13812
Endogenous sterols pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_14797
Signaling by GPCR pathway
REACT_11057
Metabolism of steroid hormones and vitamin D pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_13567
Cytochrome P450 - arranged by substrate type pathway
REACT_17015
Metabolism of proteins pathway
REACT_21340
GPCR ligand binding pathway
REACT_111217
Metabolism pathway
REACT_160078
Peptide hormone metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
REACT_210701
Peptide hormone metabolism pathway
REACT_209020
Endogenous sterols pathway
REACT_222419
G-protein activation pathway
REACT_219025
Peptide ligand-binding receptors pathway
REACT_205369
Signaling by GPCR pathway
REACT_206547
G alpha (s) signalling events pathway
REACT_226409
Phase 1 - Functionalization of compounds pathway
REACT_227682
Glucocorticoid biosynthesis pathway
REACT_218176
Biological oxidations pathway
REACT_210568
G alpha (i) signalling events pathway
REACT_214353
Signal Transduction pathway
REACT_220432
Peptide hormone biosynthesis pathway
REACT_213782
Metabolism of proteins pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_214436
GPCR downstream signaling pathway
REACT_220217
GPCR ligand binding pathway
REACT_208375
Metabolism of steroid hormones and vitamin D pathway
REACT_219139
Metabolism pathway
REACT_208412
Class A/1 (Rhodopsin-like receptors) pathway
REACT_219672
Opioid Signalling pathway
REACT_219110
Cytochrome P450 - arranged by substrate type pathway
REACT_212422
Androgen biosynthesis pathway
KEGG
hsa04920
Adipocytokine signaling pathway pathway
hsa04916
Melanogenesis pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
reg_gr_pathway
Glucocorticoid receptor regulatory network
syndecan_3_pathway
Syndecan-3-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.277996
RefSeq NM_001278581 NM_001278582 NM_001278583 NM_001278584 NM_008895
OMIM
CCDS CCDS25785
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca