InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC25A1

Summary

InnateDB Gene

IDBG-1279.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC25A1

Gene Name

solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1

Synonyms

CTP; D2L2AD; SEA; SLC20A3

Species

Homo sapiens

Ensembl Gene

ENSG00000100075

Encoded Proteins

IDBP-1281

solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1

IDBP-361581

solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The mitochondrial tricarboxylate transporter (also called citrate transport protein, or CTP) is responsible for the movement of citrate across the mitochondrial inner membrane (Kaplan et al., 1993 [PubMed 8514800]).[supplied by OMIM, Jan 2011]
This gene encodes a member of the mitochondrial carrier subfamily of solute carrier proteins. Members of this family include nuclear-encoded transporters that translocate small metabolites across the mitochondrial membrane. This protein regulates the movement of citrate across the inner membranes of the mitochondria. Mutations in this gene have been associated with combined D-2- and L-2-hydroxyglutaric aciduria. Pseudogenes of this gene have been identified on chromosomes 7, 11, 16, and 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:19175575-19178830

Strand

Reverse strand

Band

q11.21

Transcripts

ENST00000215882	ENSP00000215882
ENST00000451283	ENSP00000401480
ENST00000470922
ENST00000461267
ENST00000468824

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015137	citrate transmembrane transporter activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006810	transport
GO:0015746	citrate transport
GO:0019432	triglyceride biosynthetic process
GO:0035338	long-chain fatty-acyl-CoA biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome