Version 5.4
Mus musculus Gene: Cenpo
Summary
InnateDB Gene IDBG-127915.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cenpo
Gene Name centromere protein O
Synonyms 2810429O05Rik; 8430427C03Rik; D12Ertd482e
Species Mus musculus
Ensembl Gene ENSMUSG00000020652
Encoded Proteins
IDBP-127917
centromere protein O
IDBP-258698
centromere protein O
IDBP-538796
centromere protein O
IDBP-542643
centromere protein O
IDBP-540040
centromere protein O
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138092:
This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:4196004-4234294
Strand Reverse strand
Band A1.1
Transcripts
ENSMUST00000020981 ENSMUSP00000020981
ENSMUST00000111169 ENSMUSP00000106799
ENSMUST00000146261 ENSMUSP00000116539
ENSMUST00000140975 ENSMUSP00000119136
ENSMUST00000146523
ENSMUST00000128466 ENSMUSP00000121258
ENSMUST00000126017
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008150 biological_process
GO:0034508 centromere complex assembly
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000138092
View Gene Order
ENSBTAG00000015014
Not yet available
Pathways
NETPATH
REACTOME
REACT_249770
Cell Cycle, Mitotic pathway
REACT_233453
Chromosome Maintenance pathway
REACT_207679
Separation of Sister Chromatids pathway
REACT_198961
Resolution of Sister Chromatid Cohesion pathway
REACT_188804
Cell Cycle pathway
REACT_241408
M Phase pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_256756
Mitotic Prometaphase pathway
REACT_198595
Nucleosome assembly pathway
REACT_198597
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_202512
Mitotic Anaphase pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22186
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_22172
Chromosome Maintenance pathway
REACT_22344
Nucleosome assembly pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
REACT_216366
M Phase pathway
REACT_224944
Nucleosome assembly pathway
REACT_212887
Separation of Sister Chromatids pathway
REACT_217981
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_215084
Mitotic Metaphase and Anaphase pathway
REACT_211185
Mitotic Anaphase pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_214934
Cell Cycle pathway
REACT_227796
Chromosome Maintenance pathway
REACT_209545
Resolution of Sister Chromatid Cohesion pathway
REACT_203101
Mitotic Prometaphase pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL B8JK51
UniProt Splice Variant
Entrez Gene 52504
UniGene Mm.451301 Mm.70546
RefSeq NM_134046 XM_006515150 XM_006515152 XM_006515154 XM_006515155
OMIM
CCDS CCDS25788
HPRD
IMGT
MGI ID MGI:1923800
MGI Symbol Cenpo
EMBL AC162932 CT572999
GenPept
RNA Seq Atlas 52504

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca