Version 5.4
Mus musculus Gene: Prkaa1
Summary
InnateDB Gene IDBG-128002.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prkaa1
Gene Name protein kinase, AMP-activated, alpha 1 catalytic subunit
Synonyms AI194361; AI450832; AL024255; AMPKalpha1; C130083N04Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000050697
Encoded Proteins
IDBP-128004
protein kinase, AMP-activated, alpha 1 catalytic subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132356:
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5\'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:5143861-5181899
Strand Forward strand
Band A1
Transcripts
ENSMUST00000051186 ENSMUSP00000063166
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 61 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004679 AMP-activated protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019900 kinase binding
GO:0035174 histone serine kinase activity
GO:0046872 metal ion binding
GO:0047322 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
GO:0050321 tau-protein kinase activity
GO:0050405 [acetyl-CoA carboxylase] kinase activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0006006 glucose metabolic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006633 fatty acid biosynthetic process
GO:0006695 cholesterol biosynthetic process
GO:0006914 autophagy
GO:0008284 positive regulation of cell proliferation
GO:0008610 lipid biosynthetic process
GO:0009411 response to UV
GO:0009631 cold acclimation
GO:0010332 response to gamma radiation
GO:0010508 positive regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0014823 response to activity
GO:0016055 Wnt signaling pathway
GO:0019395 fatty acid oxidation
GO:0031000 response to caffeine
GO:0031669 cellular response to nutrient levels
GO:0032007 negative regulation of TOR signaling
GO:0035404 histone-serine phosphorylation
GO:0042149 cellular response to glucose starvation
GO:0042542 response to hydrogen peroxide
GO:0042593 glucose homeostasis
GO:0042752 regulation of circadian rhythm
GO:0043066 negative regulation of apoptotic process
GO:0045821 positive regulation of glycolytic process
GO:0048511 rhythmic process
GO:0050995 negative regulation of lipid catabolic process
GO:0051291 protein heterooligomerization
GO:0055089 fatty acid homeostasis
GO:0060627 regulation of vesicle-mediated transport
GO:0070301 cellular response to hydrogen peroxide
GO:0071361 cellular response to ethanol
GO:0071417 cellular response to organonitrogen compound
GO:0071456 cellular response to hypoxia
GO:1901563 response to camptothecin
GO:2000505 regulation of energy homeostasis
GO:2001274 negative regulation of glucose import in response to insulin stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016324 apical plasma membrane
GO:0031588 AMP-activated protein kinase complex
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000132356
View Gene Order
ENSBTAG00000000013
Not yet available
Pathways
NETPATH
REACTOME
REACT_220701
Regulation of AMPK activity via LKB1 pathway
REACT_240250
Signaling by Insulin receptor pathway
REACT_204167
Energy dependent regulation of mTOR by LKB1-AMPK pathway
REACT_259732
Insulin receptor signalling cascade pathway
REACT_188215
IRS-related events triggered by IGF1R pathway
REACT_188218
IGF1R signaling cascade pathway
REACT_188219
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_257725
Regulation of Rheb GTPase activity by AMPK pathway
REACT_240139
PI3K Cascade pathway
REACT_243154
IRS-related events pathway
REACT_242206
IRS-mediated signalling pathway
REACT_188257
Signal Transduction pathway
REACT_255725
mTOR signalling pathway
REACT_256714
PKB-mediated events pathway
KEGG
mmu04140
Regulation of autophagy pathway
mmu04910
Insulin signaling pathway pathway
mmu04150
mTOR signaling pathway pathway
mmu04920
Adipocytokine signaling pathway pathway
mmu04710
Circadian rhythm pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
REACTOME
REACT_21393
Regulation of Rheb GTPase activity by AMPK pathway
REACT_21285
Regulation of AMPK activity via LKB1 pathway
REACT_6838
mTOR signalling pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_21387
Energy dependent regulation of mTOR by LKB1-AMPK pathway
REACT_456
PKB-mediated events pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
KEGG
hsa04150
mTOR signaling pathway pathway
hsa04140
Regulation of autophagy pathway
hsa04710
Circadian rhythm pathway
hsa04910
Insulin signaling pathway pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.207004 Mm.412369
RefSeq NM_001013367 XM_006519938 XM_006519939 XM_006519940 XM_006519941 XM_006519942 XM_006519943 XM_006519944 XM_006519945 XM_006519946 XM_006519947 XM_006519948 XM_006519949 XM_006519950 XM_006519951 XM_006519952 XM_006519953
OMIM
CCDS CCDS49574
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca