Version 5.4
Mus musculus Gene: Dab2
Summary
InnateDB Gene IDBG-128034.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dab2
Gene Name disabled 2, mitogen-responsive phosphoprotein
Synonyms 5730435J12Rik; AA960054; AI957090; D15Wsu122e; D630005B22Rik; Doc-2; Doc2; p96
Species Mus musculus
Ensembl Gene ENSMUSG00000022150
Encoded Proteins
IDBP-128036
disabled homolog 2 (Drosophila)
IDBP-128040
disabled homolog 2 (Drosophila)
IDBP-259758
disabled homolog 2 (Drosophila)
IDBP-259760
disabled homolog 2 (Drosophila)
IDBP-536124
disabled homolog 2 (Drosophila)
IDBP-538782
disabled homolog 2 (Drosophila)
IDBP-537113
disabled homolog 2 (Drosophila)
IDBP-539306
disabled homolog 2 (Drosophila)
IDBP-540339
disabled homolog 2 (Drosophila)
IDBP-533779
disabled homolog 2 (Drosophila)
IDBP-536687
disabled homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153071:
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:6299788-6440712
Strand Forward strand
Band A1
Transcripts
ENSMUST00000078019 ENSMUSP00000077166
ENSMUST00000080880 ENSMUSP00000079689
ENSMUST00000110664 ENSMUSP00000106292
ENSMUST00000110663 ENSMUSP00000106291
ENSMUST00000159552
ENSMUST00000159046 ENSMUSP00000125452
ENSMUST00000161040 ENSMUSP00000124478
ENSMUST00000162140
ENSMUST00000161812 ENSMUSP00000124589
ENSMUST00000160134 ENSMUSP00000125021
ENSMUST00000159490 ENSMUSP00000124145
ENSMUST00000162094 ENSMUSP00000125696
ENSMUST00000163082 ENSMUSP00000124996
ENSMUST00000161558
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.
Experimentally validated
Total 50 [view]
Protein-Protein 48 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 64 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0008022 protein C-terminus binding
GO:0030276 clathrin binding
GO:0035091 phosphatidylinositol binding
GO:0035612 AP-2 adaptor complex binding
GO:0035615 clathrin adaptor activity
GO:0038024 cargo receptor activity
GO:0046332 SMAD binding
Biological Process
GO:0000904 cell morphogenesis involved in differentiation
GO:0001701 in utero embryonic development
GO:0001921 positive regulation of receptor recycling
GO:0001934 positive regulation of protein phosphorylation
GO:0006898 receptor-mediated endocytosis
GO:0006907 pinocytosis
GO:0006915 apoptotic process
GO:0007257 activation of JUN kinase activity
GO:0007492 endoderm development
GO:0007588 excretion
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0015031 protein transport
GO:0016055 Wnt signaling pathway
GO:0030099 myeloid cell differentiation
GO:0030335 positive regulation of cell migration
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032091 negative regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0043066 negative regulation of apoptotic process
GO:0045785 positive regulation of cell adhesion
GO:0045807 positive regulation of endocytosis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048268 clathrin coat assembly
GO:0060391 positive regulation of SMAD protein import into nucleus
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:2000096 positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway
GO:2000370 positive regulation of clathrin-mediated endocytosis
GO:2000643 positive regulation of early endosome to late endosome transport
GO:2001046 positive regulation of integrin-mediated signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0016324 apical plasma membrane
GO:0030132 clathrin coat of coated pit
GO:0030665 clathrin-coated vesicle membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070022 transforming growth factor beta receptor homodimeric complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000153071
View Gene Order
ENSBTAG00000016152
Not yet available
Pathways
NETPATH
REACTOME
REACT_224389
Gap junction trafficking and regulation pathway
REACT_209837
Membrane Trafficking pathway
REACT_220352
Formation of annular gap junctions pathway
REACT_209040
Gap junction degradation pathway
REACT_217189
Gap junction trafficking pathway
KEGG
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_8
Wnt pathway
REACTOME
REACT_11049
Formation of annular gap junctions pathway
REACT_11035
Gap junction degradation pathway
REACT_9411
Gap junction trafficking pathway
REACT_9480
Gap junction trafficking and regulation pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
tgfbrpathway
TGF-beta receptor signaling
Cross-References
SwissProt
TrEMBL E0CYJ2 E0CZ53 E9PX84
UniProt Splice Variant
Entrez Gene 13132
UniGene Mm.240830 Mm.470985 Mm.488345
RefSeq NM_001102400 NM_001008702 NM_001037905 NM_023118 XM_006519960 XM_006519961
OMIM
CCDS CCDS49576 CCDS37029 CCDS37030
HPRD
IMGT
MGI ID MGI:109175
MGI Symbol Dab2
EMBL AC099884 AC105324
GenPept
RNA Seq Atlas 13132

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca