Version 5.4
Mus musculus Gene: Pon1
Summary
InnateDB Gene IDBG-128047.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pon1
Gene Name paraoxonase 1
Synonyms Pon
Species Mus musculus
Ensembl Gene ENSMUSG00000002588
Encoded Proteins
IDBP-128049
paraoxonase 1
IDBP-714603
IDBP-715989
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005421:
The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:5168090-5193946
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000002663 ENSMUSP00000002663
ENSMUST00000177159 ENSMUSP00000135195
ENSMUST00000176945 ENSMUSP00000135728
ENSMUST00000176933
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004063 aryldialkylphosphatase activity
GO:0004064 arylesterase activity
GO:0005509 calcium ion binding
GO:0005543 phospholipid binding
GO:0008035 high-density lipoprotein particle binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008015 blood circulation
GO:0008203 cholesterol metabolic process
GO:0009636 response to toxic substance
GO:0010875 positive regulation of cholesterol efflux
GO:0016311 dephosphorylation
GO:0019439 aromatic compound catabolic process
GO:0031667 response to nutrient levels
GO:0032411 positive regulation of transporter activity
GO:0046395 carboxylic acid catabolic process
GO:0046434 organophosphate catabolic process
GO:0046470 phosphatidylcholine metabolic process
GO:0051099 positive regulation of binding
GO:0070542 response to fatty acid
GO:1902617 response to fluoride
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0034366 spherical high-density lipoprotein particle
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000005421
View Gene Order
ENSBTAG00000015654
Not yet available
Cross-References
SwissProt P52430
TrEMBL
UniProt Splice Variant
Entrez Gene 18979
UniGene Mm.237657
RefSeq NM_011134 XM_006505011
OMIM
CCDS CCDS19898
HPRD
IMGT
MGI ID MGI:103295
MGI Symbol Pon1
EMBL BC012706 L40488 U32684 U72636
GenPept AAA99445 AAB17394 AAC52496 AAH12706
RNA Seq Atlas 18979

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca