InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pdk4

Summary

InnateDB Gene

IDBG-128156.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdk4

Gene Name

pyruvate dehydrogenase kinase, isoenzyme 4

Synonyms

AV005916

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019577

Encoded Proteins

IDBP-128158

pyruvate dehydrogenase kinase, isoenzyme 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000004799:
This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:5483351-5496309

Strand

Reverse strand

Band

Transcripts

ENSMUST00000019721	ENSMUSP00000019721
ENSMUST00000134068

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005524	ATP binding

Biological Process

GO:0006006	glucose metabolic process
GO:0006086	acetyl-CoA biosynthetic process from pyruvate
GO:0006468	protein phosphorylation
GO:0006885	regulation of pH
GO:0008286	insulin receptor signaling pathway
GO:0009267	cellular response to starvation
GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010565	regulation of cellular ketone metabolic process
GO:0010906	regulation of glucose metabolic process
GO:0042304	regulation of fatty acid biosynthetic process
GO:0042593	glucose homeostasis
GO:0042594	response to starvation
GO:0045124	regulation of bone resorption
GO:0046320	regulation of fatty acid oxidation
GO:0071398	cellular response to fatty acid
GO:0072593	reactive oxygen species metabolic process
GO:2000811	negative regulation of anoikis